Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Dalton Trans. 2018 Mar 12;47(11):3669-3673. doi: 10.1039/c7dt04828a.
Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.
两种不同取代的荧光席夫碱 Ti(iv) 配合物被开发出来。一种对人类癌细胞没有活性，而另一种则表现出很高的细胞毒性。基于活细胞成像，两种配合物都能穿透细胞，但不能在核内检测到。此外，无活性的配合物被捕获在内吞小泡中，而活性的配合物则在核周区域积累，并在连续照射时产生光毒性。
