男性在与右美托咪定联合使用时，需要更高的异丙酚中靶效应室浓度来实现 I-gel 置入。

Male requires a higher median target effect-site concentration of propofol for I-gel placement when combined with dexmedetomidine.

机构信息

Department of Anaesthesiology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.

Department of Anaesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Anaesth Crit Care Pain Med. 2019 Feb;38(1):57-61. doi: 10.1016/j.accpm.2018.01.004. Epub 2018 Feb 13.

DOI:10.1016/j.accpm.2018.01.004

PMID:29452333

Abstract

OBJECTIVE

The supraglottic airway device (SAD) can be used for airway management of spontaneous breathing patients, and propofol is commonly applied for the SAD placement. This study was designed to assess the effect of gender on median target effect-site concentration (Ce) of propofol for I-gel placement when combined with dexmedetomidine.

MATERIAL AND METHOD

19 males and 18 females, aged 18 to 59 and undergoing elective surgery, were enrolled. After intravenous infusion of dexmedetomidine 1.0μg/kg over 10min followed by continuous infusion of 0.4μg/kg/h, target-controlled infusion of propofol under Marsh model was started and the initial Ce of propofol was set at 4.79μg/mL and 4.35μg/mL in the male and female patients, respectively. The I-gel was inserted when the Ce of propofol reached the pre-set concentration and bispectral index value was less than 60. The Ce of propofol required for I-gel placement was determined by the Dixon up-and-down method.

RESULTS

The Ce (95% confidence interval) of propofol required for I-gel placement were 4.082μg/mL (3.798-4.332μg/mL) and 3.509μg/mL (3.266-3.749μg/mL) in male and female patients, respectively, with a significantly higher Ce in males.

CONCLUSION

When combined with dexmedetomidine, males require a higher Ce of propofol for I-gel placement compared to females.

摘要

目的

声门上气道装置（SAD）可用于自主呼吸患者的气道管理，常应用丙泊酚进行 SAD 置管。本研究旨在评估性别对联合应用右美托咪定时丙泊酚用于 I-gel 置管的效应室靶浓度（Ce）的影响。

材料和方法

纳入 19 名男性和 18 名女性，年龄 18-59 岁，择期手术。静脉输注右美托咪定 1.0μg/kg 持续 10min 后，以 0.4μg/kg/h 的速度持续输注，采用 Marsh 模型启动丙泊酚靶控输注，初始丙泊酚 Ce 分别设定为男性和女性患者 4.79μg/ml 和 4.35μg/ml。当丙泊酚 Ce 达到预设浓度且脑电双频指数值小于 60 时，插入 I-gel。采用 Dixon 上下法确定 I-gel 置管所需要的丙泊酚 Ce。