Hischebeth Gunnar T R, Gravius Sascha, Molitor Ernst, Kohlhof Hendrik, Hoerauf Achim, Hilgers Caecilia, Randau Thomas M
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.
Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.
Diagn Microbiol Infect Dis. 2018 Jun;91(2):175-178. doi: 10.1016/j.diagmicrobio.2018.01.010. Epub 2018 Jan 31.
Antibiotic therapy is essential in foreign body associated infections. The treatment regime should aim at high tissue concentrations, high bioavailability, high biofilm penetration and good tolerance. We investigated whether the new cephalosporin ceftobiprole is active against clinical isolates from musculoskeletal foreign body associated infections. One hundred ninety-six staphylococci isolates (coagulase negative staphylococci and Staphylococcus aureus) derived from foreign body associated infections were tested towards susceptibility to ceftobiprole, using a test strip assay and broth microdilution. The MIC for all strains S. aureus indicated susceptibility to ceftobiprole. The MIC of only two strains of coagulase negative staphylococci was above 2 mg/L. Our results show that ceftobiprole might be considered as an off-label treatment option in foreign body associated infections.
抗生素治疗在与异物相关的感染中至关重要。治疗方案应旨在实现高组织浓度、高生物利用度、高生物膜穿透力和良好耐受性。我们研究了新型头孢菌素头孢比普对肌肉骨骼异物相关感染临床分离株是否有活性。使用试纸条法和肉汤微量稀释法，对196株源自异物相关感染的葡萄球菌分离株（凝固酶阴性葡萄球菌和金黄色葡萄球菌）进行了头孢比普敏感性测试。所有金黄色葡萄球菌菌株的最低抑菌浓度表明对头孢比普敏感。仅两株凝固酶阴性葡萄球菌的最低抑菌浓度高于2mg/L。我们的结果表明，头孢比普可被视为异物相关感染的一种超说明书治疗选择。
