伴侣蛋白底物为癌症药物研发提供关键一环。
Chaperone substrate provides missing link for cancer drug discovery.
机构信息
From the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46545.
出版信息
J Biol Chem. 2018 Feb 16;293(7):2381-2382. doi: 10.1074/jbc.H118.001591.
Abstract
Both Hsp70 and Hsp90 chaperones are overexpressed in cancer, making them relevant targets for the development of cancer chemotherapeutics, but a lack of biomolecular readouts for Hsp70 inhibition has limited the pursuit of specific inhibitors for this enzyme. A new study from Cesa identifies two inhibitors of apoptosis proteins (IAPs) as specific client substrates of Hsp70. These results establish biomarkers that can be utilized to monitor Hsp70 inhibition and provide a framework for future efforts to deconvolute chaperone networks.
摘要
热休克蛋白 70（Hsp70）和热休克蛋白 90（Hsp90）伴侣蛋白在癌症中过表达，这使它们成为开发癌症化疗药物的相关靶点，但由于缺乏用于 Hsp70 抑制的生物分子读出，限制了对该酶的特异性抑制剂的研究。Cesa 的一项新研究鉴定了两种凋亡蛋白抑制因子（IAPs）作为 Hsp70 的特异性客户底物。这些结果确定了可用于监测 Hsp70 抑制的生物标志物，并为未来解开伴侣蛋白网络的工作提供了框架。
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