结扎后心脏综合征与早产儿发病率增加有关。
Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants.
作者信息
Ulrich Timothy J B, Hansen Taylor P, Reid Kimberly J, Bingler Michael A, Olsen Steven L
机构信息
Department of pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.
Department of Health Services and Outcomes Research, Children's Mercy Hospital, Kansas City, MO, USA.
出版信息
J Perinatol. 2018 May;38(5):537-542. doi: 10.1038/s41372-018-0056-4. Epub 2018 Feb 16.
OBJECTIVE
The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP).
STUDY DESIGN
Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups. Secondary outcomes included discharge with home oxygen and severe ROP.
RESULT
A total of 100 infants that underwent PDA ligation during the study period were included in the study; 31 (31%) neonates developed PLCS. In adjusted analysis, PLCS was associated with increased risk for severe BPD (RR 1.67, 95% CI: 1.15-2.42) and home oxygen therapy (RR: 1.47, 95% CI: 1.09-1.99) only. No association with severe ROP was seen (RR: 1.48; 95% CI: 0.87-2.52).
CONCLUSION
PLCS is associated with severe neonatal pulmonary morbidity, but not with severe ROP. Further investigation is warranted to validate these results.
目的
动脉导管未闭（PDA）结扎术的并发症——结扎后心脏综合征（PLCS）对新生儿结局的影响尚不清楚。本研究的目的是确定PLCS对严重肺部疾病和重度早产儿视网膜病变（ROP）的风险。
研究设计
对2006年至2015年间接受PDA结扎术的婴儿进行回顾性队列研究。收集有和没有PLCS的患者的数据。主要结局是两组之间严重支气管肺发育不良（BPD）的差异。次要结局包括出院时携带家庭用氧和重度ROP。
结果
共有100例在研究期间接受PDA结扎术的婴儿纳入研究；31例（31%）新生儿发生PLCS。在校正分析中，PLCS仅与严重BPD风险增加（RR 1.67，95% CI：1.15 - 2.42）和家庭氧疗（RR：1.47, 95% CI：1.09 - 1.99）相关。未发现与重度ROP有关联（RR：1.48；95% CI：0.87 - 2.52）。
结论
PLCS与新生儿严重肺部疾病相关，但与重度ROP无关。有必要进行进一步研究以验证这些结果。
Zotero 插件