早产中NODAL基因变异与炎症的基因-环境相互作用的证据。
Evidence of a gene-environment interaction of NODAL variants and inflammation in preterm birth.
作者信息
Starr Lisa M, Ayash Taghreed A, Dufort Daniel
机构信息
Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada.
Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
出版信息
J Perinatol. 2018 May;38(5):482-488. doi: 10.1038/s41372-018-0073-3. Epub 2018 Feb 16.
OBJECTIVE
NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth.
STUDY DESIGN
For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation.
RESULT
NODAL polymorphisms were not associated with preterm birth. However, the rs2231947(C>T) variant allele was associated with increased risk for preterm birth among women with bacterial vaginosis (odds ratio: 2.76, 95% confidence interval: 1.12-6.85). Among women without placental inflammation, the rs1904589(A>G) variant allele was associated with increased risk of preterm birth (odds ratio: 1.31, 95% confidence interval: 1.02-1.70). Among women with placental inflammation, the rs10999338(C>T) variant allele was associated with reduced risk of preterm birth (odds ratio: 0.50, 95% confidence interval: 0.29-0.87).
CONCLUSION
The effect of NODAL polymorphisms on preterm birth depends on maternal infection/inflammation status.
目的
NODAL与分娩时间及免疫调节有关。我们研究了NODAL基因多态性、感染/炎症与早产之间的关系。
研究设计
在这项二次分析中，对来自蒙特利尔早产研究的613名女性（189名早产女性和424名足月产女性）进行了NODAL基因多态性基因分型，并评估了细菌性阴道病和胎盘炎症情况。
结果
NODAL基因多态性与早产无关。然而，rs2231947（C>T）变异等位基因与患细菌性阴道病的女性早产风险增加有关（比值比：2.76，95%置信区间：1.12 - 6.85）。在无胎盘炎症的女性中，rs1904589（A>G）变异等位基因与早产风险增加有关（比值比：1.31，95%置信区间：1.02 - 1.70）。在有胎盘炎症的女性中，rs10999338（C>T）变异等位基因与早产风险降低有关（比值比：0.50，95%置信区间：0.29 - 0.87）。
结论
NODAL基因多态性对早产的影响取决于母亲的感染/炎症状态。
Zotero 插件