尼泊尔中部一家三级护理医院肝硬化患者的人口统计学和临床概况

Demographic and Clinical Profile in Patients with Liver Cirrhosis in a Tertiary Care Hospital in Central Nepal.

作者信息

Bhattarai Subash, Gyawali Merina, Dewan Khus Raj, Shrestha Gaurav

机构信息

Department of Medical Gastroenterology, College of Medical Sciences, Chitwan, Nepal.

Department of Radiodiagnosis and Imaging, Manipal College of Medical Sciences, Pokhara, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2017 Oct-Dec;56(208):401-6.

PMID:29453469

Abstract

INTRODUCTION

Liver cirrhosis is an important health problem worldwide and is a common disease in Nepal. The profile of cirrhosis may vary due to different factors. This study was undertaken to see the demographic and clinical profiles of patients with cirrhosis of liver attending a tertiary care hospital in Central Nepal.

METHODS

Six hundred patients with clinical features, laboratory and sonological findings suggestive of chronic liver dysfunction and endoscopic evidence of portal hypertension were included in the study. Their demographic and clinical profile, endoscopic findings, outcomes during hospitalization were studied. Ethical approval was taken from Institutional Review Committee of College of Medical Sciences. SPSS 20 was used for statistical analysis.

RESULTS

The mean age of subjects was 54±11.84 years with 435 males (72.5%) and 165 (27.5%) females. Majority of 203 (33.8%) patients were from Mongol ethnicity followed by 127 (21.2%) Khas. Two hundred and twenty (36.6%) were farmers followed by 169 (28.2%) retired personnel. A total of 338 (56.4 %) patients were from rural areas. The commonest aetiology of cirrhosis was chronic alcohol consumption and seen in 552 (92%) patients. Abdominal distension was commonest presenting sign and observed in 561 (93.5%) patients. Ascites seen in 555 (92.5%) patients was the commonest complication followed by UGI bleed in 326 (54.3%) patients. Gastro-oesophageal varices observed in 345 (57.5%) patients, was the most common endoscopic finding followed by portal gastropathy, peptic ulcer and erosive mucosal diseases. In patient mortality was noted in 92 (15.3 %) patients.

CONCLUSIONS

This study highlights the burden of cirrhosis, usually caused by chronic alcohol consumption in Central Nepal. Majority of subjects were male, middle aged, farmers, from rural areas and predominantly observed in some ethnicity like Mongols. Cirrhotic patients usually Keywords: cirrhosis of liver; complications; endoscopy.

摘要

引言

肝硬化是一个全球性的重要健康问题，在尼泊尔也是一种常见疾病。由于不同因素，肝硬化的情况可能有所不同。本研究旨在了解尼泊尔中部一家三级医院收治的肝硬化患者的人口统计学和临床特征。

方法

本研究纳入了600例具有慢性肝功能障碍临床特征、实验室及超声检查结果，并有门静脉高压内镜证据的患者。研究了他们的人口统计学和临床特征、内镜检查结果以及住院期间的结局。获得了医学科学学院机构审查委员会的伦理批准。使用SPSS 20进行统计分析。

结果

研究对象的平均年龄为54±11.84岁，其中男性435例（72.5%），女性165例（27.5%）。203例（33.8%）患者大多数为蒙古族，其次是127例（21.2%）卡族。220例（36.6%）为农民，其次是169例（28.2%）退休人员。共有338例（56.4%）患者来自农村地区。肝硬化最常见的病因是长期饮酒，552例（92%）患者存在该情况。腹胀是最常见的症状，561例（93.5%）患者出现该症状。555例（92.5%）患者出现腹水是最常见的并发症，其次是326例（54.3%）患者发生上消化道出血。345例（57.5%）患者观察到胃食管静脉曲张，是最常见的内镜检查发现，其次是门静脉性胃病、消化性溃疡和糜烂性黏膜疾病。92例（15.3%）患者出现死亡。