Arnaiz-Villena Antonio, Palacio-Grüber Jose, Juarez Ignacio, Hernández Ennio, Muñiz Ester, Bayona Brayan, Campos Cristina, Nieto Jorge, Martin-Villa Manuel, Silvera Carlos
Department of Immunology, University Complutense, School of Medicine, Madrid Regional Blood Center, Madrid, Spain.
Department of Immunology, University Complutense, School of Medicine, Madrid Regional Blood Center, Madrid, Spain.
Hum Immunol. 2018 Apr;79(4):189-190. doi: 10.1016/j.humimm.2018.02.004. Epub 2018 Feb 14.
HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A24:02-B51:10-C15:02-BRB104:07-DQB103:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A24:02), but not in others that belong to the same or different HLA loci.
通过高分辨率分子分型技术，对来自萨瓦纳·德·圣安赫尔（北哥伦比亚海岸）的奇米拉美洲印第安人进行了HLA - A、- B、- C、- DRB1和 - DQB1等位基因的研究。发现了一种常见的扩展单倍型：HLA - A24:02 - B51:10 - C15:02 - BRB104:07 - DQB103:02（28.7%），该单倍型在墨西哥的美洲印第安人马约斯人群（墨西哥、加利福尼亚湾、太平洋）中也有描述。其他单倍型已在来自墨西哥（太平洋和大西洋海岸）、秘鲁（高地和亚马逊盆地）、玻利维亚和美国北部的美洲印第安人中发现。正如所知，美洲印第安人缺乏根据HLA等位基因或单倍型频率形成的地理模式。此外，在奇米拉美洲印第安人中发现了五种新的扩展单倍型。其HLA - A24:02高频率特征与台湾原住民群体相同；同样，HLA - C01:02高频率在新西兰毛利人、新喀里多尼亚人和澳大利亚的金伯利原住民中也有发现。最后，本研究可能展示了一种进化因素作用的模式，即一个HLA等位基因频率（- A24:02）上升，但属于相同或不同HLA位点的其他等位基因频率并未上升。
