Department of Urology, Charles University, Medical Faculty, Charles University Hospital Plzen, Czech Republic.
Department of Pathology, Charles University, Medical Faculty, Charles University Hospital Plzen, Czech Republic.
Ann Diagn Pathol. 2019 Jun;40:189-199. doi: 10.1016/j.anndiagpath.2017.11.004. Epub 2017 Nov 8.
Traditionally, papillary renal cell carcinomas (PRCCs) have been divided in two subgroups - type 1 and type 2. Based on recent molecular and genetic developments in the understanding of RCCs, it seems that this traditional classification may not be adequate and that the spectrum of PRCCs is much wider than initially proposed. Small series of distinct types of PRCC which do not fit into the above mentioned categories have been described in the literature. Published studies investigating molecular genetic changes in various types of PRCCs have shown that the molecular genetic features are remarkably heterogeneous across the whole spectrum of PRCCs. Of all PRCC subtypes/variants, PRCC type 1 seems to be a genetically uniform group, while other types showed different degrees of heterogeneity. Among different molecular-genetic features, chromosomal numerical aberration status is one of the most frequently studied features so far. It is becoming more evident that tumor type-specific chromosomal numerical aberration status in PRCCs may not exist. In this review, we present the most current knowledge concerning chromosomal numerical aberration status in PRCCs.
传统上，肾乳头状细胞癌（PRCC）可分为两个亚组 - 1 型和 2 型。基于对 RCC 认识的最新分子和遗传学进展，这种传统分类可能不够充分，PRCC 的范围比最初提出的要广泛得多。文献中已经描述了一些不符合上述类别的不同类型的 PRCC。发表的研究调查了各种类型的 PRCC 中的分子遗传变化，表明整个 PRCC 范围内的分子遗传特征具有显著的异质性。在所有的 PRCC 亚型/变体中，PRCC 1 型似乎是一组遗传上均匀的群体，而其他类型则表现出不同程度的异质性。在不同的分子遗传特征中，染色体数目异常状态是迄今为止研究最多的特征之一。越来越明显的是，PRCC 中肿瘤类型特异性的染色体数目异常状态可能不存在。在这篇综述中，我们介绍了关于 PRCC 中染色体数目异常状态的最新知识。
