Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada; Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Can J Cardiol. 2018 Apr;34(4):429-436. doi: 10.1016/j.cjca.2017.11.022. Epub 2017 Dec 6.
Atrial fibrillation (AF) is a chronic progressive disease characterized by exacerbations and remissions. It remains the most common sustained arrhythmia seen in clinical practice, and represents a major burden to health care systems. Similar to other cardiovascular conditions, significant sex-specific differences have been observed in the epidemiology (lower rate of prevalence in women, women present at a later age), pathophysiology (sex-related differences in AF triggers and substrate), clinical presentation (women are more likely symptomatic, with relatively more severe symptoms), and natural history. Moreover, similar to other cardiovascular conditions there are substantial sex-specific differences in the management of AF, with women being significantly less likely to receive therapeutic anticoagulation, attempts at rhythm control, or undergo invasive cardiovascular procedures. The purpose of this review is to explore these sex-specific differences.
心房颤动（AF）是一种慢性进行性疾病，其特征为加重和缓解。它仍然是临床实践中最常见的持续性心律失常，对医疗保健系统构成了重大负担。与其他心血管疾病类似，在流行病学（女性患病率较低，女性发病年龄较晚）、病理生理学（AF 触发因素和基质中的性别相关差异）、临床表现（女性更有可能出现症状，症状相对更严重）和自然病史方面都观察到了明显的性别差异。此外，与其他心血管疾病类似，在 AF 的管理方面也存在着显著的性别差异，女性接受治疗性抗凝、节律控制尝试或接受有创心血管手术的可能性明显较低。本综述的目的是探讨这些性别差异。
