Fuah Kar Wah, Lim Christopher T S, Pang Daniel C L, Wong Jin Shyan
Department of Nephrology, Serdang Hospital, Selangor, Malaysia.
Department of Medicine, Bintulu Hospital, Sarawak, Malaysia.
Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):207-209. doi: 10.4103/1319-2442.225177.
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce seizure episodes. We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period.
氨甲环酸（TXA）是一种常用于实现止血的抗纤维蛋白溶解剂。然而，有一些病例报告表明，高剂量静脉注射TXA具有致癫痫特性。在肾功能损害患者中，即使给予通常推荐剂量的TXA也可能诱发癫痫发作。我们在此报告一名接受血液透析的患者，该患者在5小时内接受两剂TXA后出现癫痫发作。
