kratom中毒致死及脂肪乳剂的可能作用
Death from Kratom toxicity and the possible role of intralipid.
作者信息
Aggarwal Geeta, Robertson Edward, McKinlay James, Walter Edward
机构信息
Department of Intensive Care, Royal Surrey County Hospital, Guildford, UK.
出版信息
J Intensive Care Soc. 2018 Feb;19(1):61-63. doi: 10.1177/1751143717712652. Epub 2017 Jun 13.
Abstract
We present the case of a 26-year-old man who was brought into our emergency department in cardiorespiratory arrest, having taken Kratom 24 h previously. Despite multi-organ support, he deteriorated and died from cardiorespiratory failure and hypoxic brain damage 12 h later. Lipid emulsion was given, with significant temporary improvement in the cardiorespiratory failure. Kratom is derived from Mitragyna speciosa, a tropical deciduous and evergreen tree in the coffee family, and is native to Southeast Asia, and its leaves are used as a legal high in some parts of the world. Here, we review the pharmacochemistry of the drug, and wish to highlight that the effects of Kratom may not be as benign as are commonly reported, and the possible role of intralipid in managing the Kratom toxicity in this case.
摘要
我们报告一例26岁男性病例，该患者在24小时前服用了 kratom 后，被送入我们的急诊科时已处于心肺骤停状态。尽管给予了多器官支持，但他的病情仍恶化，并在12小时后死于心肺衰竭和缺氧性脑损伤。给予了脂质乳剂，心肺衰竭有显著的暂时改善。Kratom 源自帽柱木属植物，是茜草科的一种热带落叶和常绿乔木，原产于东南亚，其叶子在世界某些地区被用作合法的兴奋剂。在此，我们回顾该药物的药物化学，并希望强调 kratom 的作用可能不像通常报道的那样良性，以及脂质乳剂在处理该病例中 kratom 毒性方面的可能作用。
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