Yang Jin-Shan, Wei Hui-Xing, Chen Ping-Ping, Wu Gang
Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, P.R. China.
Exp Ther Med. 2018 Mar;15(3):2219-2227. doi: 10.3892/etm.2018.5702. Epub 2018 Jan 4.
Multiple cellular components are involved in the complex pathological process following central nervous system (CNS) injury, including neurons, glial cells and endothelial cells. Previous studies and neurotherapeutic clinical trials have assessed the molecular mechanisms that underlie neuronal cell death following CNS injury. However, this approach has largely failed to reduce CNS damage or improve the functional recovery of patients. Erythropoietin-producing human hepatocellular (Eph) receptors and ephrin ligands have attracted considerable attention since their discovery, due to their extensive distribution and unique bidirectional signaling between astrocytes and neurons. Previous studies have investigated the roles of Eph/ephrin bidirectional signaling in the developing central nervous system. It was determined that Eph/ephrin bidirectional signaling is expressed in various CNS regions and cell types, and that it serves diverse roles in the adult CNS. In the present review, the roles of Eph/ephrin bidirectional signaling in CNS injuries are assessed.
多种细胞成分参与中枢神经系统（CNS）损伤后的复杂病理过程，包括神经元、神经胶质细胞和内皮细胞。先前的研究和神经治疗临床试验评估了中枢神经系统损伤后神经元细胞死亡的分子机制。然而，这种方法在很大程度上未能减少中枢神经系统损伤或改善患者的功能恢复。自发现以来，促红细胞生成素产生的人肝细胞（Eph）受体和ephrin配体因其广泛分布以及星形胶质细胞和神经元之间独特的双向信号传导而备受关注。先前的研究调查了Eph/ephrin双向信号在发育中的中枢神经系统中的作用。已确定Eph/ephrin双向信号在中枢神经系统的各个区域和细胞类型中表达，并且在成体中枢神经系统中发挥多种作用。在本综述中，评估了Eph/ephrin双向信号在中枢神经系统损伤中的作用。
