Department of Paediatrics,The Medical University of Warsaw,Żwirki i Wigury 63A, 02-091 Warsaw,Poland.
Br J Nutr. 2018 Apr;119(7):810-825. doi: 10.1017/S0007114518000120. Epub 2018 Feb 19.
In 2011, the Committee on Nutrition of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition systematically reviewed published evidence related to the safety and health effects of the administration of formulae supplemented with pro- and/or prebiotics compared with unsupplemented formulae. We updated evidence on the effects of the administration of prebiotic-supplemented infant formulae (IF) compared with unsupplemented IF. Five databases were searched up to March 2017 for randomised controlled trials. In all, forty-one publications were identified, including twenty-five new publications. The administration of currently evaluated prebiotic-supplemented formulae to healthy infants does not raise safety concerns with regard to growth and adverse effects. Some favourable clinical effects are possible, primarily stool softening, which may be beneficial in some infants. Currently, there is no existing robust evidence to recommend the routine use of prebiotic-supplemented formulae. The latter conclusion may reflect the small amount of data on specific prebiotics and outcomes, rather than a genuine lack of an effect. The efficacy and safety should be considered for each prebiotic(s)-supplemented formula.
2011 年，欧洲儿科胃肠病学、肝病学和营养学学会营养委员会系统地回顾了已发表的关于配方中添加益生元和/或益生菌与未添加相比的安全性和健康影响的证据。我们更新了关于添加益生元的婴儿配方（IF）与未添加 IF 相比的效果的证据。截至 2017 年 3 月，对五个数据库进行了随机对照试验搜索。总共确定了 41 篇出版物，包括 25 篇新出版物。目前评估的添加益生元的配方对健康婴儿的生长和不良反应没有安全问题。一些有益的临床效果是可能的，主要是使粪便软化，这在某些婴儿中可能是有益的。目前，没有确凿的证据推荐常规使用添加益生元的配方。这一结论可能反映了关于特定益生元和结果的数据较少，而不是真正缺乏效果。应考虑每种添加益生元的配方的功效和安全性。
