从合萌（Albizia zygia (DC.) J. F. Macbr.）茎皮中鉴定出两种新的阿拉伯胶酸型皂苷的结构
Structural determination of two new acacic acid-type saponins from the stem barks of Albizia zygia (DC.) J. F. Macbr.
作者信息
Noté Olivier Placide, Simo Line Made, Mbing Joséphine Ngo, Guillaume Dominique, Muller Christian Dominique, Pegnyemb Dieudonné Emmanuel, Lobstein Annelise
机构信息
a Faculté de Pharmacie, Laboratoire d'Innovation Thérapeutique, UMR 7200 , CNRS-Université de Strasbourg , Illkirch Cedex , France.
b Faculté de Sciences, Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique , Université de Yaoundé I , Yaoundé , Cameroun.
出版信息
Nat Prod Res. 2019 Jan;33(2):180-188. doi: 10.1080/14786419.2018.1440228. Epub 2018 Feb 19.
As a continuation of our interest in the study of triterpenoid saponins from Albizia zygia, phytochemical investigation of its stem barks led to the isolation of two new oleanane-type saponins, named zygiaosides C-D (1-2). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as, 3-O-[ β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (1) and 3- O-[β-d-glucopyranosyl-(1→2) -[ β-d-fucopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (2).
作为我们对合欢属植物三萜皂苷研究兴趣的延续，对其茎皮进行植物化学研究，从中分离出两种新的齐墩果烷型皂苷，命名为合欢皂苷C - D（1 - 2）。它们的结构是在对一维和二维核磁共振（1H -、13C NMR、DEPT、COSY、TOCSY、ROESY、HSQC和HMBC）实验进行广泛分析、高分辨电喷雾电离质谱（HRESIMS）研究以及化学证据的基础上确定的，分别为3 - O - [β - D - 吡喃葡萄糖基 - (1→2) - [α - L - 阿拉伯吡喃糖基 - (1→6)] - β - D - 吡喃葡萄糖基] - 21 - O - [(2E,6S) - 2,6 - 二甲基 - 6 - O - (β - D - 奎诺吡喃糖基) 辛 - 2,7 - 二烯酰] 金合欢酸28 - O - α - L - 阿拉伯呋喃糖基 - (1→4) - [β - D - 吡喃葡萄糖基 - (1→3)] - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 吡喃葡萄糖基酯（1）和3 - O - [β - D - 吡喃葡萄糖基 - (1→2) - [β - D - 岩藻吡喃糖基 - (1→6)] - β - D - 吡喃葡萄糖基] - 21 - O - [(2E,6S) - 2,6 - 二甲基 - 6 - O - (β - D - 奎诺吡喃糖基) 辛 - 2,7 - 二烯酰] 金合欢酸28 - O - α - L - 阿拉伯呋喃糖基 - (1→4) - [β - D - 吡喃葡萄糖基 - (1→3)] - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 吡喃葡萄糖基酯（2）。
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