Noté Olivier Placide, Simo Line Made, Mbing Joséphine Ngo, Guillaume Dominique, Muller Christian Dominique, Pegnyemb Dieudonné Emmanuel, Lobstein Annelise
a Faculté de Pharmacie, Laboratoire d'Innovation Thérapeutique, UMR 7200 , CNRS-Université de Strasbourg , Illkirch Cedex , France.
b Faculté de Sciences, Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique , Université de Yaoundé I , Yaoundé , Cameroun.
Nat Prod Res. 2019 Jan;33(2):180-188. doi: 10.1080/14786419.2018.1440228. Epub 2018 Feb 19.
As a continuation of our interest in the study of triterpenoid saponins from Albizia zygia, phytochemical investigation of its stem barks led to the isolation of two new oleanane-type saponins, named zygiaosides C-D (1-2). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as, 3-O-[ β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (1) and 3- O-[β-d-glucopyranosyl-(1→2) -[ β-d-fucopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (2).
作为我们对合欢属植物三萜皂苷研究兴趣的延续，对其茎皮进行植物化学研究，从中分离出两种新的齐墩果烷型皂苷，命名为合欢皂苷C - D（1 - 2）。它们的结构是在对一维和二维核磁共振（1H -、13C NMR、DEPT、COSY、TOCSY、ROESY、HSQC和HMBC）实验进行广泛分析、高分辨电喷雾电离质谱（HRESIMS）研究以及化学证据的基础上确定的，分别为3 - O - [β - D - 吡喃葡萄糖基 - (1→2) - [α - L - 阿拉伯吡喃糖基 - (1→6)] - β - D - 吡喃葡萄糖基] - 21 - O - [(2E,6S) - 2,6 - 二甲基 - 6 - O - (β - D - 奎诺吡喃糖基) 辛 - 2,7 - 二烯酰] 金合欢酸28 - O - α - L - 阿拉伯呋喃糖基 - (1→4) - [β - D - 吡喃葡萄糖基 - (1→3)] - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 吡喃葡萄糖基酯（1）和3 - O - [β - D - 吡喃葡萄糖基 - (1→2) - [β - D - 岩藻吡喃糖基 - (1→6)] - β - D - 吡喃葡萄糖基] - 21 - O - [(2E,6S) - 2,6 - 二甲基 - 6 - O - (β - D - 奎诺吡喃糖基) 辛 - 2,7 - 二烯酰] 金合欢酸28 - O - α - L - 阿拉伯呋喃糖基 - (1→4) - [β - D - 吡喃葡萄糖基 - (1→3)] - α - L - 鼠李吡喃糖基 - (1→2) - β - D - 吡喃葡萄糖基酯（2）。
