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Radiosynthesis and in Vivo Evaluation of [C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand.
J Med Chem. 2018 Mar 8;61(5):2118-2123. doi: 10.1021/acs.jmedchem.8b00028. Epub 2018 Feb 23.
2
In vivo comparison of N-CH vs O-CH radiolabeled microtubule targeted PET ligands.
Bioorg Med Chem Lett. 2020 Jan 15;30(2):126785. doi: 10.1016/j.bmcl.2019.126785. Epub 2019 Nov 9.
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Preclinical evaluation of a microtubule PET ligand [C]MPC-6827 in tau and amyotrophic lateral sclerosis animal models.
Pharmacol Rep. 2022 Jun;74(3):539-544. doi: 10.1007/s43440-022-00359-y. Epub 2022 Mar 14.
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In vivo evaluation of a microtubule PET ligand, [C]MPC-6827, in mice following chronic alcohol consumption.
Pharmacol Rep. 2022 Feb;74(1):241-247. doi: 10.1007/s43440-021-00311-6. Epub 2021 Sep 7.
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PET Imaging of [C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains.
Molecules. 2020 May 13;25(10):2289. doi: 10.3390/molecules25102289.
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Effect of ethanol and cocaine on [C]MPC-6827 uptake in SH-SY5Y cells.
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Radiosynthesis and Evaluation of [C]HD-800, a High Affinity Brain Penetrant PET Tracer for Imaging Microtubules.
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Initial Evaluations of the Microtubule-Based PET Radiotracer, [C]MPC-6827 in a Rodent Model of Cocaine Abuse.
Front Med (Lausanne). 2022 Feb 28;9:817274. doi: 10.3389/fmed.2022.817274. eCollection 2022.

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Radiation-induced brain injury in non-human primates: A dual tracer PET study with [C]MPC-6827 and [C]PiB.
Neuroimage Rep. 2025 Mar;5(1). doi: 10.1016/j.ynirp.2025.100245. Epub 2025 Feb 19.
2
Imaging of Microtubules in a Nonhuman Primate Model of Alcohol Use Disorder.
ACS Pharmacol Transl Sci. 2025 Apr 8;8(5):1313-1319. doi: 10.1021/acsptsci.4c00682. eCollection 2025 May 9.
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Development and Optimization of C-Labeled Radiotracers: A Review of the Modern Quality Control Design Process.
ACS Pharmacol Transl Sci. 2023 Oct 11;6(11):1616-1631. doi: 10.1021/acsptsci.3c00200. eCollection 2023 Nov 10.
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Preliminary PET Imaging of Microtubule-Based PET Radioligand [C]MPC-6827 in a Nonhuman Primate Model of Alzheimer's Disease.
ACS Chem Neurosci. 2023 Oct 18;14(20):3745-3751. doi: 10.1021/acschemneuro.3c00527. Epub 2023 Sep 19.
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First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations.
J Med Chem. 2023 Jul 13;66(13):9120-9129. doi: 10.1021/acs.jmedchem.3c00720. Epub 2023 Jun 14.
7
Binding Parameters of [C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents.
Pharmaceuticals (Basel). 2023 Mar 27;16(4):495. doi: 10.3390/ph16040495.
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[F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates.
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Glioblastoma: Current Status, Emerging Targets, and Recent Advances.
J Med Chem. 2022 Jul 14;65(13):8596-8685. doi: 10.1021/acs.jmedchem.1c01946. Epub 2022 Jul 5.

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Taxol: The First Microtubule Stabilizing Agent.
Int J Mol Sci. 2017 Aug 9;18(8):1733. doi: 10.3390/ijms18081733.
2
Radiosynthesis and evaluation of IGF1R PET ligand [C]GSK1838705A.
Bioorg Med Chem Lett. 2017 Jul 1;27(13):2895-2897. doi: 10.1016/j.bmcl.2017.04.085. Epub 2017 Apr 27.
3
Radiolabeling and initial biological evaluation of [F]KBM-1 for imaging RAR-α receptors in neuroblastoma.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1425-1427. doi: 10.1016/j.bmcl.2017.01.093. Epub 2017 Feb 1.
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Of microtubules and memory: implications for microtubule dynamics in dendrites and spines.
Mol Biol Cell. 2017 Jan 1;28(1):1-8. doi: 10.1091/mbc.E15-11-0769.
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Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.
Neurobiol Dis. 2017 Sep;105:328-335. doi: 10.1016/j.nbd.2016.12.021. Epub 2016 Dec 22.
7
A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease.
Front Cell Neurosci. 2016 Sep 13;10:204. doi: 10.3389/fncel.2016.00204. eCollection 2016.
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Faulty splicing and cytoskeleton abnormalities in Huntington's disease.
Brain Pathol. 2016 Nov;26(6):772-778. doi: 10.1111/bpa.12430.
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Anti-Microtubule Drugs.
Methods Mol Biol. 2016;1413:403-21. doi: 10.1007/978-1-4939-3542-0_25.
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The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders.
Prog Neurobiol. 2016 Jun;141:61-82. doi: 10.1016/j.pneurobio.2016.04.007. Epub 2016 Apr 16.

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