Department of Pathology, Shihezi University School of Medicine, Xinjiang 832002, China.
Department of Pathology, Zhucheng Maternal and Child Care Service Centre, Weifang 262200, China.
Hum Pathol. 2018 Aug;78:171-176. doi: 10.1016/j.humpath.2018.02.012. Epub 2018 Feb 17.
Ovarian microcystic stromal tumor is a relatively rare tumor type. This tumor is characterized by a unique microcyst structure, and essentially all tumors show benign biological behavior. Here, we report a case with a primary ovarian microcystic stromal tumor that experienced recurrence. Pathological findings showed that the original tumor, relapsed tumor in the ovary, and the recurrent tumor in the iliac fossa presented similar histologic features. The tumor mainly consisted of microcysts, solid cellular regions, and a fibrous stroma. Immunohistochemically, the tumor cells were positive for β-catenin, CD10, vimentin, and WT-1. Mutational analysis revealed a missense mutation (c.1590C>T; pG530E) in exon 15 of the APC gene and another missense mutation (c.740G>A; pA247V) in exon 1 of the KRAS gene. We also reviewed other published cases to evaluate the prognosis and treatment. This is the first report to describe a microcystic stromal tumor of the ovary presenting with undetermined biological potential.
卵巢微囊性间质瘤是一种相对罕见的肿瘤类型。该肿瘤的特征为独特的微囊结构，基本上所有肿瘤均表现出良性的生物学行为。在此，我们报告了一例原发性卵巢微囊性间质瘤复发的病例。病理检查结果显示，原始肿瘤、卵巢复发性肿瘤和髂窝复发性肿瘤均呈现出相似的组织学特征。肿瘤主要由微囊、实性细胞区和纤维基质组成。免疫组化结果显示，肿瘤细胞表达β-catenin、CD10、波形蛋白和 WT-1。突变分析显示 APC 基因外显子 15 存在错义突变（c.1590C>T;pG530E），KRAS 基因外显子 1 存在另一个错义突变（c.740G>A;pA247V）。我们还复习了其他已发表的病例，以评估其预后和治疗。这是首例描述具有不确定生物学潜能的卵巢微囊性间质瘤的病例。
