卵巢微囊性间质瘤伴巢蛋白显著表达：独特病例报告。
Ovarian Microcystic Stromal Tumor with Significant Nestin Expression: A Unique Case.
机构信息
Department of Histology and Embryology, School of Basic Medicine, Chifeng University, China.
Department of Urology, University of Yamanashi, Japan.
出版信息
Intern Med. 2024 Oct 15;63(20):2781-2785. doi: 10.2169/internalmedicine.3221-23. Epub 2024 Mar 4.
Ovary microcystic stromal tumor (MCST) is an extremely rare subtype of sex cord-stromal neoplasm, and only 57 cases have been reported. We herein report a unique case of ovarian MCST with positive nestin expression in a 39-year-old Chinese woman. The tumor showed microcystic stromal histological structures and characteristically expressed the CD10, WT-1, and Ki67 proteins. A molecular analysis identified a point mutation (c.110C > T) in exon 3 of the CTNNB1 gene. To our knowledge, no report has described a case of ovarian MCST with positive staining for nestin protein. Our study provides new insights into the tumor biology of ovarian MCST.
卵巢微囊型基质瘤（MCST）是一种极为罕见的性索-间质肿瘤亚型，仅有 57 例报道。本文报道了一例独特的卵巢 MCST 病例，患者为 39 岁中国女性，巢蛋白呈阳性表达。肿瘤呈微囊型基质组织学结构，特征性表达 CD10、WT-1 和 Ki67 蛋白。分子分析发现 CTNNB1 基因外显子 3 存在点突变（c.110C > T）。据我们所知，尚无巢蛋白阳性染色的卵巢 MCST 病例报道。本研究为卵巢 MCST 的肿瘤生物学提供了新的见解。
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