Carlberg Katie T, Singer Sylvia T, Vichinsky Elliott P
Hematology Oncology, UCSF Benioff Children's Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA.
Hematology Oncology, UCSF Benioff Children's Hospital Oakland, 747 52nd Street, Oakland, CA 94609, USA.
Hematol Oncol Clin North Am. 2018 Apr;32(2):297-315. doi: 10.1016/j.hoc.2017.11.004.
As more women with transfusion-dependent thalassemia are seeking pregnancy, ensuring the best outcomes for both the mother and baby requires concerted, collaborative efforts between practitioners and the family. Proactive counseling, early fertility evaluation, recent developments in reproductive technology, and optimal management of iron overload, have resulted in more successful pregnancies and the birth of healthy newborns. With advances in technology for prenatal screening and increased awareness to perform screening for hemoglobinopathies, healthy pregnancy outcomes have become the expectation. Topics that require further study include management that allows fertility preservation, improved non-invasive prenatal diagnosis methods for affected fetuses, the use of chelation therapy during pregnancy, and indications for and duration of anticoagulation.
随着越来越多依赖输血的地中海贫血女性寻求怀孕，要确保母婴都获得最佳结果，从业者和家庭之间需要齐心协力、共同合作。积极的咨询、早期生育评估、生殖技术的最新进展以及铁过载的优化管理，已带来了更成功的妊娠和健康新生儿的诞生。随着产前筛查技术的进步以及对血红蛋白病进行筛查的意识增强，健康的妊娠结局已成为人们的期望。需要进一步研究的主题包括允许保留生育能力的管理方法、针对受影响胎儿的改进的非侵入性产前诊断方法、孕期螯合疗法的使用以及抗凝的指征和持续时间。
