剖宫产术后镇痛硬膜外吗啡所致瘙痒的药物遗传学研究
Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia.
作者信息
Kung Chia-Chi, Chen Shiou-Sheng, Yang Hong-Jyh, Lai Chih-Jun, Chen Li-Kuei
机构信息
Department of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, Taiwan.
Department of Urology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan; Division of Urology, Taipei City Hospital Heping Fuyou Branch, 100, Taipei, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2018 Feb;57(1):89-94. doi: 10.1016/j.tjog.2017.12.015.
OBJECTIVE
The mechanism through which neuroaxial morphine causes pruritus has not been elucidated clearly and thoroughly.
MATERIALS AND METHODS
a study in 129 female parturients was conducted to investigate the effect of 14 single nucleotide polymorphisms (SNPs) on phenotype (pruritus) induced by neuroaxial (including intrathecal or epidural) morphine for cesarean section. Clinical phenotype, subjective complaints and objective observations were recorded. DNA from blood samples was used to record the SNPs. Eleven SNPs were then analyzed further.
RESULTS
no significant association with the presence of phenotype (pruritus) versus genotype was observed (all p-values > 0.05). No significant association with severity of phenotype versus genotype of the 11 SNPs was observed except for unadjusted data for rs2737703. There was no significant difference between severity or incidence of IVPCA morphine-induced nausea and vomiting and genotype (11 SNPs).
CONCLUSION
our results showed no association between SNPs of any of the genes studied with neuroaxial morphine inducing pruritus.
目的
神经轴索吗啡引起瘙痒的机制尚未得到清晰和全面的阐明。
材料与方法
对129名女性产妇进行一项研究，以调查14个单核苷酸多态性（SNP）对剖宫产时神经轴索（包括鞘内或硬膜外）吗啡诱导的表型（瘙痒）的影响。记录临床表型、主观症状和客观观察结果。采集血样提取DNA以记录SNP。然后对11个SNP进行进一步分析。
结果
未观察到表型（瘙痒）的存在与基因型之间存在显著关联（所有p值>0.05）。除rs2737703的未校正数据外，未观察到11个SNP的表型严重程度与基因型之间存在显著关联。静脉自控镇痛（IVPCA）吗啡引起的恶心和呕吐的严重程度或发生率与基因型（11个SNP）之间无显著差异。
结论
我们的结果表明，所研究的任何基因的SNP与神经轴索吗啡诱导的瘙痒之间均无关联。
Zotero 插件