抗原特异性、MHC非限制性T辅助细胞诱导的B细胞活化。
Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation.
作者信息
Friedman S M, Jover J A, Chartash E K, Crow M K
出版信息
J Exp Med. 1986 Nov 1;164(5):1773-8. doi: 10.1084/jem.164.5.1773.
Abstract
We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.
摘要
我们使用了一个克隆的、针对三硝基苯（TNP）特异性的、受主要组织相容性复合体（MHC）限制的人T辅助（Th）细胞系E-11，以及一种同源Th-B细胞相互作用的检测方法，即B细胞表面BLAST-2抗原的表达，来研究Th细胞抗原受体的功能特性。我们观察到，E-11以半抗原依赖、半抗原特异性但不受MHC限制的方式诱导静息B细胞表达BLAST-2。讨论了这些结果对Th细胞受体的意义。
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Immune response (Ir) genes of the murine major histocompatibility complex.小鼠主要组织相容性复合体的免疫应答（Ir）基因。
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9
10
Direct T helper-B cell interactions induce an early B cell activation antigen.直接的辅助性T细胞- B细胞相互作用诱导早期B细胞活化抗原。
J Exp Med. 1986 Nov 1;164(5):1760-72. doi: 10.1084/jem.164.5.1760.
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