开发用于治疗传染病的蛋白质-蛋白质相互作用抑制剂。
Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.
机构信息
University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
出版信息
Adv Protein Chem Struct Biol. 2018;111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24.
Abstract
Protein-protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible for making PPI inhibitors realistic targets for therapeutic intervention and brief outlook of the field.
摘要
蛋白质-蛋白质相互作用（PPI）抑制剂是一类快速发展的治疗药物。我们对 PPI 的理解的最新进展和早期 PPI 抑制剂的成功范例证明了靶向 PPI 的可行性。本综述总结了用于发现和优化多种 PPI 抑制剂的技术，重点是将 PPI 抑制剂开发为新型抗菌和抗病毒药物。最后，我们总结了使 PPI 抑制剂成为治疗干预的现实目标的进展，并简要展望了该领域的前景。
相似文献
1
Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.
Adv Protein Chem Struct Biol. 2018;111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24.
2
Targeting protein-protein interactions: a promising avenue of anti-HIV drug discovery.
Curr Med Chem. 2010;17(29):3393-409. doi: 10.2174/092986710793176357.
3
[Advances in novel anti-HIV-1 drugs and drug candidates: 2005-2008].
Yao Xue Xue Bao. 2010 Feb;45(2):154-64.
4
EDITORIAL: New Avenues in Controlling Infectious Diseases.
Curr Top Med Chem. 2017;17(19):2113. doi: 10.2174/156802661719170616164549.
5
Structure Based Drug Design: Clinically Relevant HIV-1 Integrase Inhibitors.
Curr Top Med Chem. 2018;18(31):2664-2680. doi: 10.2174/1568026619666190119143239.
6
Naphthoxazepine inhibitors of HIV-1 integrase: synthesis and biological evaluation.
ChemMedChem. 2008 Jun;3(6):986-90. doi: 10.1002/cmdc.200800026.
7
Discovery and analysis of inhibitors of the human immunodeficiency integrase.
Drug Des Discov. 1997 May;15(1):17-24.
8
Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):665-8. doi: 10.1080/15257770701490563.
9
Antiviral research--21st international conference.
IDrugs. 2008 Jun;11(6):401-4.
10
Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase.
Bioorg Med Chem. 2015 Sep 1;23(17):5247-63. doi: 10.1016/j.bmc.2015.06.016. Epub 2015 Jun 14.
引用本文的文献
1
Hot-Spot-Guided Generative Deep Learning for Drug-Like PPI Inhibitor Design.
Interdiscip Sci. 2025 Sep 2. doi: 10.1007/s12539-025-00756-w.
2
Polymers for Disrupting Protein-Protein Interactions: Where Are We and Where Should We Be?
Biomacromolecules. 2024 Oct 14;25(10):6229-6249. doi: 10.1021/acs.biomac.4c00850. Epub 2024 Sep 10.
3
Rational design of small-sized peptidomimetic inhibitors disrupting protein-protein interaction.
RSC Med Chem. 2024 May 7;15(7):2212-2225. doi: 10.1039/d4md00202d. eCollection 2024 Jul 17.
4
Molecular Determinants of Human Rhinovirus Infection, Assembly, and Conformational Stability at Capsid Protein Interfaces.
J Virol. 2022 Dec 14;96(23):e0084022. doi: 10.1128/jvi.00840-22. Epub 2022 Nov 14.
5
Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model.
Pharmaceuticals (Basel). 2022 Jun 22;15(7):773. doi: 10.3390/ph15070773.
6
Protein-Protein Binding Free Energy Predictions with the MM/PBSA Approach Complemented with the Gaussian-Based Method for Entropy Estimation.
ACS Omega. 2022 Mar 22;7(13):11057-11067. doi: 10.1021/acsomega.1c07037. eCollection 2022 Apr 5.
7
Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex.
mBio. 2021 Aug 31;12(4):e0134821. doi: 10.1128/mBio.01348-21. Epub 2021 Aug 10.
8
Structural Profiling of Bacterial Effectors Reveals Enrichment of Host-Interacting Domains and Motifs.
Front Mol Biosci. 2021 May 3;8:626600. doi: 10.3389/fmolb.2021.626600. eCollection 2021.
9
Resources and computational strategies to advance small molecule SARS-CoV-2 discovery: Lessons from the pandemic and preparing for future health crises.
Comput Struct Biotechnol J. 2021;19:2537-2548. doi: 10.1016/j.csbj.2021.04.059. Epub 2021 Apr 26.
10
Scanning Protein Surfaces with DNA-Encoded Libraries.
ChemMedChem. 2021 Apr 8;16(7):1048-1062. doi: 10.1002/cmdc.202000869. Epub 2020 Dec 28.
本文引用的文献
1
A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail.
Lancet Infect Dis. 2017 Feb;17(2):e56-e63. doi: 10.1016/S1473-3099(16)30386-3. Epub 2016 Nov 18.
2
Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.
J Biol Chem. 2016 Dec 9;291(50):25965-25982. doi: 10.1074/jbc.M116.741884. Epub 2016 Oct 4.
3
Redefining the roles of the FtsZ-ring in bacterial cytokinesis.
Curr Opin Microbiol. 2016 Dec;34:90-96. doi: 10.1016/j.mib.2016.08.008. Epub 2016 Sep 10.
4
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
ACS Med Chem Lett. 2016 Jun 9;7(8):797-801. doi: 10.1021/acsmedchemlett.6b00194. eCollection 2016 Aug 11.
5
Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.
Sci Rep. 2016 Apr 1;6:23815. doi: 10.1038/srep23815.
6
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.
Database (Oxford). 2016 Mar 15;2016. doi: 10.1093/database/baw007. Print 2016.
7
2015 Update of the Drug Resistance Mutations in HIV-1.
Top Antivir Med. 2015 Oct-Nov;23(4):132-41.
8
Why Do We Need New Drug Classes for HIV Treatment and Prevention?
Curr Top Med Chem. 2016;16(12):1343-9. doi: 10.2174/1568026616999151013124606.
9
The emerging threat of multidrug-resistant Gram-negative bacteria in urology.
Nat Rev Urol. 2015 Oct;12(10):570-84. doi: 10.1038/nrurol.2015.199. Epub 2015 Sep 1.
10
State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.
Chem Soc Rev. 2015 Nov 21;44(22):8238-59. doi: 10.1039/c5cs00252d. Epub 2015 Aug 6.
Zotero 插件