University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Adv Protein Chem Struct Biol. 2018;111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24.
Protein-protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible for making PPI inhibitors realistic targets for therapeutic intervention and brief outlook of the field.
蛋白质-蛋白质相互作用（PPI）抑制剂是一类快速发展的治疗药物。我们对 PPI 的理解的最新进展和早期 PPI 抑制剂的成功范例证明了靶向 PPI 的可行性。本综述总结了用于发现和优化多种 PPI 抑制剂的技术，重点是将 PPI 抑制剂开发为新型抗菌和抗病毒药物。最后，我们总结了使 PPI 抑制剂成为治疗干预的现实目标的进展，并简要展望了该领域的前景。
