Hartin Samantha N, Hossain Waheeda A, Manzardo Ann M, Brown Shaquanna, Fite Paula J, Bortolato Marco, Butler Merlin G
Departments of Psychiatry & Behavioral Sciences and Pediatrics and Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA), University of Kansas Medical Center, Kansas City, KS, USA.
Clinical Child Psychology Program and Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA), University of Kansas, Lawrence, KS, USA.
Growth Horm IGF Res. 2018 Aug;41:48-53. doi: 10.1016/j.ghir.2018.02.004. Epub 2018 Feb 12.
The first study of growth hormone receptor (GHR) genotypes in healthy young adults in the United States attending a Midwestern university and impact on selected growth parameters.
To describe the frequency of GHR genotypes in a sample of healthy young adults from the United States attending a university in the Midwest and analyze the relationship between GHR genotypes and selected growth parameters.
Saliva was collected from 459 healthy young adults (237 females, 222 males; age range = 18-25 y) and DNA isolated for genotyping of GHR alleles (fl/fl, fl/d3, or d3/d3). Selected growth parameters were collected and GHR genotype data examined for previously reported associations (e.g., height, weight or bone mass density) or novel findings (e.g., % body water and index finger length).
We found 219 participants (48%) homozygous for fl/fl, 203 (44%), heterozygous fl/d3 and 37 (8%) homozygous d3/d3. The distribution of GHR genotypes in our participants was consistent with previous reports of non-US populations. Several anthropometric measures differed by sex. The distribution of GHR genotypes did not significantly differ by sex, weight, or other anthropometric measures. However, the fl/d3 genotype was more common among African-Americans.
Our study of growth and anthropometric parameters in relationship to GHR genotypes found no association with height, weight, right index finger length, BMI, bone mass density, % body fat or % body water in healthy young adults. We did identify sex differences with increased body fat, decreased bone density, body water and index finger length in females.
对美国中西部一所大学的健康年轻成年人的生长激素受体（GHR）基因型进行的首次研究及其对选定生长参数的影响。
描述来自美国中西部一所大学的健康年轻成年人样本中GHR基因型的频率，并分析GHR基因型与选定生长参数之间的关系。
从459名健康年轻成年人（237名女性，222名男性；年龄范围=18 - 25岁）中收集唾液，并分离DNA以对GHR等位基因（fl/fl、fl/d3或d3/d3）进行基因分型。收集选定的生长参数，并检查GHR基因型数据与先前报道的关联（如身高、体重或骨密度）或新发现（如身体水分百分比和食指长度）。
我们发现219名参与者（48%）为fl/fl纯合子，203名（44%）为fl/d3杂合子，37名（8%）为d3/d3纯合子。我们参与者中GHR基因型的分布与先前非美国人群的报道一致。几项人体测量指标存在性别差异。GHR基因型的分布在性别、体重或其他人体测量指标方面没有显著差异。然而，fl/d3基因型在非裔美国人中更为常见。
我们对与GHR基因型相关的生长和人体测量参数的研究发现，在健康年轻成年人中，身高、体重、右手食指长度、BMI、骨密度、体脂百分比或身体水分百分比与之无关联。我们确实发现了性别差异，女性的体脂增加、骨密度降低、身体水分和食指长度减少。
