School of Sciences/Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China.
School of Sciences/Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China.
Colloids Surf B Biointerfaces. 2018 May 1;165:111-117. doi: 10.1016/j.colsurfb.2018.02.017. Epub 2018 Feb 12.
DL-mandelic acid (MA) has been intercalated into Zn-Al layered double hydroxide (LDH) by an anion-exchange reaction. After intercalation of MA anions, the basal spacing of the LDH increased from 0.75 to 1.46 nm, suggesting that the MA anions were successfully intercalated into the interlayer galleries of the LDH. The structure and the thermal stability of the samples were characterized by XRD, FT-IR, TG-DTA. Studies of MA release from ZnAl-MA-LDH in hydrochloric solution (pH = 4) imply that ZnAl-MA-LDH is a better controlled release system than pure MA. Meanwhile, the mechanisms of slow release were assessed by using four commonly kinetic models. Finally, the antimicrobial activity of ZnAl-MA-LDH was tested against two kinds of bacteria and a fungus. The study confirms that the mandelic ions intercalated LDHs have the potential application as a slow release preservative in the future.
DL-扁桃酸（MA）通过阴离子交换反应被嵌入到 Zn-Al 层状双氢氧化物（LDH）中。MA 阴离子嵌入后，LDH 的基面间距从 0.75nm 增加到 1.46nm，表明 MA 阴离子成功地嵌入到 LDH 的层间空隙中。通过 XRD、FT-IR、TG-DTA 对样品的结构和热稳定性进行了表征。在盐酸溶液（pH=4）中从 ZnAl-MA-LDH 中释放 MA 的研究表明，ZnAl-MA-LDH 是一种比纯 MA 更好的控制释放体系。同时，使用四种常见的动力学模型评估了缓慢释放的机制。最后，测试了 ZnAl-MA-LDH 对两种细菌和一种真菌的抗菌活性。研究证实，扁桃酸离子嵌入 LDH 具有作为未来的一种缓慢释放防腐剂的潜在应用。
