Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Br J Ophthalmol. 2018 Dec;102(12):1723-1727. doi: 10.1136/bjophthalmol-2017-311533. Epub 2018 Feb 19.
Sebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.
This was a retrospective, single-centre cohort study. Patients with surgically resected eyelid SGC between January 2001 and May 2015 at the Hong Kong Eye Hospital were reviewed. Tumours were staged using the AJCC criteria. The main outcome measures included local recurrence, metastasis and death. Disease-free survival (DFS) was measured from the completion of treatment; overall survival was measured from the date of initial diagnosis.
The study included 22 Chinese patients with a mean age of 65.4 years. The majority presented as a nodular lesion (91%) with 12 eyes (54.5%) initially misdiagnosed and a mean presentation time of 1 year. It was found that those with AJCC stage T2b or higher were significantly associated with lymph node metastasis (P=0.002) when compared with those with stage T2a. Older age at diagnosis (P=0.035) and no misdiagnosis (P=0.025) were associated with shorter DFS. Those with stage 3a or higher were associated with shorter DFS (P=0.007) and overall survival (P=0.024).
Similar to previous reports, in this Chinese cohort, AJCC staging for SGC correlated with lymph node metastasis, DFS and overall survival. Those with stage 2b or higher on presentation will need closer surveillance for lymph node metastasis and may benefit from sentinel lymph node biopsy.
眼睑皮脂腺癌（SGC）是一种罕见但具有潜在致命性的癌症。本研究旨在确定美国癌症联合委员会（AJCC）第 7 版 T 分期是否与中国人群中的转移和生存相关。
这是一项回顾性、单中心队列研究。回顾了 2001 年 1 月至 2015 年 5 月期间在香港眼科医院接受手术切除的眼睑 SGC 患者。使用 AJCC 标准对肿瘤进行分期。主要观察指标包括局部复发、转移和死亡。无病生存（DFS）从治疗完成时开始测量；总生存从初始诊断日期开始测量。
该研究纳入了 22 名平均年龄为 65.4 岁的中国患者。大多数患者表现为结节性病变（91%），12 只眼（54.5%）最初误诊，平均发病时间为 1 年。发现 AJCC 分期 T2b 或更高的患者与 T2a 患者相比，淋巴结转移的显著相关（P=0.002）。诊断时年龄较大（P=0.035）和无误诊（P=0.025）与较短的 DFS 相关。分期为 3a 或更高的患者与较短的 DFS（P=0.007）和总生存（P=0.024）相关。
与之前的报告类似，在这个中国队列中，AJCC 分期与 SGC 的淋巴结转移、DFS 和总生存相关。那些在就诊时处于 2b 或更高分期的患者需要更密切监测淋巴结转移，可能受益于前哨淋巴结活检。
