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磁共振成像在鼻窦肿物评估中的应用及其与组织病理学的相关性

Magnetic Resonance Imaging in Evaluation of Sinonasal Masses with Histopathological Correlation.

作者信息

Begum M S, Sarker U K, Islam M A, Sangma M A, Paul P, Rahman M A

机构信息

Dr Mst Shahnwaz Begum, Assistant Professor, Prime Medical College & Hospital, Rangpur, Bangladesh.

出版信息

Mymensingh Med J. 2018 Jan;27(1):26-33.

Abstract

Sinonasal mass is the abnormal growth of tissue from nasal cavity and mucosa of the paranasal sinuses. The growth may be benign or malignant. The benign lesion grows slowly and does not metastasize. The malignant lesion grows rapidly and metastasizes early. The aim of this study is to evaluate and diagnose the various types of sinonasal masses with MRI and its correlation with histopathological findings. This cross sectional descriptive study was carried out for a period of 02 years, from July 2015 to June 2017. The patients were selected from the ENT outpatient department and from the department Radiology & Imaging of Mymensingh Medical College Hospital, Mymensingh, Bangladesh who were reported as case of sinonasal masses. Thirty three (33) patients (17 males and 16 females) with sinonasal masses were included after fulfilling exclusion & inclusion criteria which was confirmed by proper clinical examination & were subjected to MRI and histopathological examination. The age range was 11 to 85 years. The nasal cavity was the most commonly involved site with sinonasal malignancies (were 4 cases, 12.12%) followed by the maxillary sinuses (were 2 cases, 6.06%). The least commonly affected site was the frontal sinuses (was 1 case, 3.03%). Histopathological findings shows benign sinonasal tumors were present in 25 cases. The most common benign lesion was sinonasal polyposis 10 cases (30.30%), followed by inverted papilloma 6 cases (18.18%) & juvenile nasopharyngeal angiofibroma 6 cases (18.18%), adenoma 02 cases (6.06%), and one case was rhinosporidiosis (3.03%). Malignant sinonasal tumors were present in 8 cases. Most common malignant tumors were nasopharyngeal carcinoma in 4 cases (12.12%), adenoid cystic carcinoma in 3 cases (9.09%) and non-Hodgkin lymphoma was present in 01 case (3.03%). MRI report shows benign masses in 23 cases of which nasopharyngeal polyposis was 10(30.30%), inverted papilloma 6(18.18%), juvenile angiofibroma 4(12.12%), adenoma 02(6.06%) & rhinosporidiosis 1(3.03%). Among 10 malignant tumors nasopharyngeal carcinoma were 6(18.18%), adenoid cystic carcinoma 3(9.09%) & non-Hodgkin lymphoma 1(3.03%). MRI findings of malignant sinonasal masses revealed that sensitivity 87.5%, specificity 40.0%, positive predictive value (PPV) 70% & negative predictive value 66%. Statistically significant association was observed between histopathology & MRI findings, p value was 0.305. Statistically significant association was found between histopathology & MRI findings.

摘要

鼻窦肿物是鼻腔和鼻窦黏膜组织的异常生长。这种生长可能是良性的,也可能是恶性的。良性病变生长缓慢,不会发生转移。恶性病变生长迅速,且早期就会转移。本研究的目的是利用磁共振成像(MRI)评估和诊断各种类型的鼻窦肿物,并探讨其与组织病理学结果的相关性。这项横断面描述性研究为期2年,从2015年7月至2017年6月。研究对象选自孟加拉国迈门辛医学院医院耳鼻喉科门诊以及放射影像科,这些患者均被诊断为鼻窦肿物。经过严格的排除和纳入标准筛选后,最终纳入33例(17例男性和16例女性)鼻窦肿物患者,这些标准通过适当的临床检查得以确认,随后对患者进行了MRI和组织病理学检查。患者年龄范围为11至85岁。鼻腔是鼻窦恶性肿瘤最常累及的部位(4例,占12.12%),其次是上颌窦(2例,占6.06%)。受影响最少的部位是额窦(1例,占3.03%)。组织病理学结果显示,25例为良性鼻窦肿瘤。最常见的良性病变是鼻窦息肉10例(占30.30%),其次是内翻性乳头状瘤6例(占18.18%)和青少年鼻咽血管纤维瘤6例(占18.18%),腺瘤2例(占6.06%),鼻孢子虫病1例(占3.03%)。恶性鼻窦肿瘤有8例。最常见的恶性肿瘤是鼻咽癌4例(占12.12%),腺样囊性癌3例(占9.09%),非霍奇金淋巴瘤1例(占3.03%)。MRI报告显示,23例为良性肿物,其中鼻窦息肉10例(占30.30%),内翻性乳头状瘤6例(占18.18%),青少年血管纤维瘤4例(占12.12%),腺瘤2例(占6.06%),鼻孢子虫病1例(占3.03%)。在10例恶性肿瘤中,鼻咽癌6例(占18.18%),腺样囊性癌3例(占9.09%),非霍奇金淋巴瘤1例(占3.03%)。鼻窦恶性肿物的MRI检查结果显示,敏感性为87.5%,特异性为40.0%,阳性预测值(PPV)为70%,阴性预测值为66%。组织病理学与MRI检查结果之间存在统计学显著关联,p值为0.305。组织病理学与MRI检查结果之间发现有统计学显著关联。

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