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大鼠肺静脉心肌的结构异质性：对细胞内钙动力学和致心律失常潜能的影响。

Structural heterogeneity of the rat pulmonary vein myocardium: consequences on intracellular calcium dynamics and arrhythmogenic potential.

机构信息

CNRS ERL 7368, Signalisation et Transports Ioniques Membranaires, Equipe Transferts Ioniques et Rythmicité Cardiaque, Groupe Physiologie des Cellules Cardiaques et Vasculaires, Tours, France.

CNRS ERL 7368, Signalisation et Transports Ioniques Membranaires, Equipe Transferts Ioniques et Rythmicité Cardiaque, Poitiers, France.

出版信息

Sci Rep. 2018 Feb 19;8(1):3244. doi: 10.1038/s41598-018-21671-9.

DOI:10.1038/s41598-018-21671-9
PMID:29459735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5818479/
Abstract

Mechanisms underlying ectopic activity in the pulmonary vein (PV) which triggers paroxysmal atrial fibrillation are unknown. Although several studies have suggested that calcium signalling might be involved in these arrhythmias, little is known about calcium cycling in PV cardiomyocytes (CM). We found that individual PV CM showed a wide range of transverse tubular incidence and organization, going from their virtual absence, as described in atrial CM, to well transversally organised tubular systems, like in ventricular CM. These different types of CM were found in groups scattered throughout the tissue. The variability of the tubular system was associated with cell to cell heterogeneity of calcium channel (Ca1.2) localisation and, thereby, of Ca1.2-Ryanodine receptor coupling. This was responsible for multiple forms of PV CM calcium transient. Spontaneous calcium sparks and waves were not only more abundant in PV CM than in LA CM but also associated with a higher depolarising current. In conclusion, compared with either the atrium or the ventricle, PV myocardium presents marked structural and functional heterogeneity.

摘要

导致阵发性心房颤动的肺静脉（PV）异位活动的机制尚不清楚。尽管有几项研究表明钙信号可能参与这些心律失常，但关于 PV 心肌细胞（CM）中的钙循环知之甚少。我们发现，单个 PV CM 表现出广泛的横管发生率和组织，从它们的虚拟缺失，如在心房 CM 中描述的，到良好的横向组织管状系统，如在心室 CM 中。这些不同类型的 CM 分布在整个组织中。管状系统的可变性与钙通道（Ca1.2）定位的细胞间异质性有关，从而与 Ca1.2-ryanodine 受体偶联有关。这导致了多种形式的 PV CM 钙瞬变。与 LA CM 相比，PV CM 不仅自发性钙火花和波更丰富，而且还与更高的去极化电流相关。总之，与心房或心室相比，PV 心肌表现出明显的结构和功能异质性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/7883581bd40b/41598_2018_21671_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/8b7fd3683a26/41598_2018_21671_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/7883581bd40b/41598_2018_21671_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/b3207cdc7a45/41598_2018_21671_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/eeffb9db426d/41598_2018_21671_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/a64bd9059753/41598_2018_21671_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/538beb4e2e61/41598_2018_21671_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/ebdc68da70fd/41598_2018_21671_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/8b7fd3683a26/41598_2018_21671_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d82c/5818479/7883581bd40b/41598_2018_21671_Fig7_HTML.jpg

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