Shahrabi Saeid, Behzad Masumeh Maleki, Jaseb Kaveh, Saki Najmaldin
Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Research Center of Thalassemia and Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Histol Histopathol. 2018 Sep;33(9):895-908. doi: 10.14670/HH-11-976. Epub 2018 Feb 20.
Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to identify the conditions associated with the incidence of thrombocytopenia in leukemias. It can be stated that although translocations have been considered responsible for this complication in many studies, other factors such as bone marrow failure, genes polymorphism, a mutation in some transcription factors, and the adverse effects of treatment could be associated with pathogenesis and poor prognosis of thrombocytopenia in leukemias. Considering the importance of thrombocytopenia in leukemias, it is hoped that the recognition of risk factors increasing the incidence of this complication in leukemic patients would be useful for prevention and treatment of this disorder.
白血病是一组异质性血液系统疾病，其特征为造血功能无效及造血细胞形态异常。血小板减少是白血病类型中常见的问题，可导致患者出现出血并发症。这篇综述文章的目的是确定与白血病患者血小板减少发生率相关的情况。可以说，尽管在许多研究中易位被认为是导致这种并发症的原因，但其他因素，如骨髓衰竭、基因多态性、某些转录因子的突变以及治疗的不良反应，可能与白血病患者血小板减少的发病机制和不良预后有关。鉴于血小板减少在白血病中的重要性，希望识别增加白血病患者这种并发症发生率的危险因素将有助于预防和治疗这种疾病。
