Ayyat Kamal S, Okamoto Toshihiro, Niikawa Hiromichi, McCurry Kenneth R
Department of Pathobiology, Cleveland Clinic, Cleveland, OH, USA.
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.
Interact Cardiovasc Thorac Surg. 2018 Jul 1;27(1):145-147. doi: 10.1093/icvts/ivy041.
We present an innovative method for recruiting clinically rejected donor lungs using positive end-expiratory pressure titration during ex vivo lung perfusion. Currently, ex vivo lung perfusion protocols are using a standard positive end-expiratory pressure of 5 cmH2O for all cases. Individualized positive end-expiratory pressure titration combined with recruitment manoeuvres has been found to significantly improve pulmonary functions in mechanically ventilated patients. Applying this concept to ex vivo lung perfusion may be helpful in increasing the conversion rate for transplant suitability.
我们提出了一种在体外肺灌注过程中使用呼气末正压滴定法来招募临床上被拒绝的供体肺的创新方法。目前，体外肺灌注方案在所有病例中都使用5厘米水柱的标准呼气末正压。已发现个体化呼气末正压滴定结合肺复张手法可显著改善机械通气患者的肺功能。将这一概念应用于体外肺灌注可能有助于提高移植适宜性的转化率。
