Schaumberg Debra A, McDonald Laura, Shah Surbhi, Stokes Michael, Nordstrom Beth L, Ramagopalan Sreeram V
Real-World Evidence, Evidera, Waltham, MA 02451, USA.
Center for Observational Research & Data Sciences, Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.
J Comp Eff Res. 2018 May;7(5):503-515. doi: 10.2217/cer-2018-0007. Epub 2018 Feb 21.
Comparative effectiveness research (CER) guidelines have been developed to direct the field toward the most rigorous study methodologies. A challenge, however, is how to ensure the best evidence is generated, and how to translate methodologically complex or nuanced CER findings into usable medical evidence. To reach that goal, it is important that both researchers and end users of CER output become knowledgeable about the elements that impact the quality and interpretability of CER. This paper distilled guidance on CER into a practical tool to assist both researchers and nonexperts with the critical review and interpretation of CER, with a focus on issues particularly relevant to CER in oncology.
比较效果研究（CER）指南已经制定出来，以引导该领域采用最严格的研究方法。然而，一个挑战是如何确保产生最佳证据，以及如何将方法复杂或细微差别的CER结果转化为可用的医学证据。为了实现这一目标，CER产出的研究人员和最终用户都了解影响CER质量和可解释性的因素非常重要。本文将CER指南提炼成一个实用工具，以协助研究人员和非专家对CER进行批判性审查和解释，重点关注肿瘤学中与CER特别相关的问题。
