Schreiber-Zamora Joanna, Szpotanska-Sikorska Monika, Czaplinska Natalia, Drozdowska-Szymczak Agnieszka, Pietrzak Bronisława, Wielgos Mirosław, Kociszewska-Najman Bozena
a Neonatology Ward, 1st Department of Obstetrics and Gynecology , Medical University of Warsaw , Warszawa , Poland.
b 1st Department of Obstetrics and Gynecology , Medical University of Warsaw , Warszawa , Poland.
J Matern Fetal Neonatal Med. 2019 Aug;32(15):2512-2516. doi: 10.1080/14767058.2018.1439468. Epub 2018 Feb 20.
Overweight and obesity are one of the most serious clinical health problems. Until now, the long-term development of children born to mothers after transplantation is unknown. In this study, we attempted to present the analysis of the prevalence of overweight in the population of mothers after kidney or liver transplants.
A comparison of body mass index (BMI) measurements performed in 61 children of kidney transplant women (study group) and 64 children born to healthy mothers (control group). The children from both groups were born at a similar gestational age and in the similar time period from 12/1996 to 11/2010. BMI was measured once on one of the follow-up visits in the time period from 07/2010 to 11/2013. BMI was assessed in infants older than one month as well as in toddlers or children in the preschool or school age. The results obtained in the study group of children born to transplanted mothers were compared with control group results and with the theoretical population data.
There were no differences in the incidence of underweight and overweight, when BMI values of children born to transplanted mothers were compared to those of children of healthy mothers. There was a trend towards a greater incidence of obesity in children of studied group compared to controls (16 versus 6%, p = .072). Among analysed factors, it was noted that prenatal exposure to tacrolimus was associated with a 2.8-fold increased risk of developing a higher BMI in later follow-up.
Obesity among children of mothers after kidney or liver transplants seems to be more frequently observed. This observation may be an important factor in the further paediatric care, especially in children born to transplanted mothers treated chronically with tacrolimus.
超重和肥胖是最严重的临床健康问题之一。迄今为止，移植后母亲所生孩子的长期发育情况尚不清楚。在本研究中，我们试图对肾移植或肝移植后母亲群体中超重的患病率进行分析。
对61名肾移植女性的子女（研究组）和64名健康母亲所生孩子（对照组）的体重指数（BMI）测量结果进行比较。两组儿童的出生孕周相似，均在1996年12月至2010年11月的同一时间段内出生。在2010年7月至2013年11月期间的一次随访中测量BMI。对1个月以上的婴儿以及学龄前或学龄期的幼儿或儿童进行BMI评估。将移植母亲所生孩子的研究组结果与对照组结果以及理论人群数据进行比较。
将移植母亲所生孩子的BMI值与健康母亲所生孩子的BMI值进行比较时，体重过轻和超重的发生率没有差异。与对照组相比，研究组儿童肥胖发生率有升高趋势（16%对6%，p = 0.072）。在分析的因素中，注意到产前接触他克莫司与后期随访中BMI升高风险增加2.8倍有关。
肾移植或肝移植后母亲的子女中肥胖似乎更常见。这一观察结果可能是进一步儿科护理中的一个重要因素，尤其是对于长期接受他克莫司治疗的移植母亲所生的孩子。
