Andrisani A, Sabbadin C, Marin L, Ragazzi E, Dessole F, Armanini D, Donà G, Bordin L, Ambrosini G
a Department of Women's and Children's Health , Salus Pueri, University of Padua , Padua , Italy.
b Department of Medicine (DIMED), Endocrinology Unit , University of Padua , Padua , Italy.
Gynecol Endocrinol. 2018 Sep;34(9):752-755. doi: 10.1080/09513590.2018.1442427. Epub 2018 Feb 20.
The influence of thyroid autoimmunity in assisted reproductive technology (ART) outcome in euthyroid women is still controversial. In this study, we retrospectively evaluated embryo quality in 123 euthyroid women undergoing ART with or without thyroid autoantibodies (TAA). Embryo quality was assessed in 119 embryos of 29 infertile patients with TAA and in 394 embryos of 94 infertile patients without TAA. Our results showed not statistically significant differences in age, body mass index, anti-Müllerian hormone, follicle stimulating hormone, free triiodothyronine, and free thyroxine levels between cases and controls. Thyroid stimulating hormone was within the normal range, but significantly higher in TAA patients compared with the controls (2.4 ± 0.8 vs. 2 ± 0.9 mIU/L, respectively, p < .01). The number of oocytes picked up and fertilized was comparable between the two groups. Embryo quality was significantly impaired in women with at least one autoantibody (p < .001). Implantation rate, pregnancy rate, and ongoing pregnancy rate were comparable in the two groups. These results suggest a negative impact of thyroid autoimmunity in embryo quality in women undergoing ART even when thyroid function is normal.
甲状腺自身免疫对甲状腺功能正常的女性辅助生殖技术（ART）结局的影响仍存在争议。在本研究中，我们回顾性评估了123名接受ART的甲状腺功能正常且有或无甲状腺自身抗体（TAA）的女性的胚胎质量。对29名有TAA的不孕患者的119个胚胎以及94名无TAA的不孕患者的394个胚胎进行了胚胎质量评估。我们的结果显示，病例组和对照组在年龄、体重指数、抗苗勒管激素、促卵泡激素、游离三碘甲状腺原氨酸和游离甲状腺素水平方面无统计学显著差异。促甲状腺激素在正常范围内，但TAA患者的促甲状腺激素水平显著高于对照组（分别为2.4±0.8与2±0.9 mIU/L，p<0.01）。两组间采集和受精的卵母细胞数量相当。至少有一项自身抗体的女性胚胎质量显著受损（p<0.001）。两组间的着床率、妊娠率和持续妊娠率相当。这些结果表明，即使甲状腺功能正常，甲状腺自身免疫对接受ART的女性胚胎质量也有负面影响。
