Grégoire V, Gueulette J, Octave-Prignot M, De Coster B M, Wambersie A
C R Seances Soc Biol Fil. 1986;180(3):372-8.
Lung tolerance is assessed from LD50 at 180 days after thoracic irradiation, in mice, with d(50) + Be neutrons and 60Co gamma rays. Early intestinal tolerance is assessed from LD50 at 7 days after abdominal irradiation. Additional dose (Dr) to reach LD50 when a single dose Ds is split into 2 equal fractions Di separated by different time intervals "i", is determined (Dr = 2Di - Ds), Dr is larger after gamma than after neutron irradiation, for lung and intestine. After thoracic irradiation with gamma rays, Dr reaches 3.36, 4.38, 5.12 and 5.37 Gy for "i" = 2, 6, 12 and 24 hours respectively; after neutron irradiation, Dr reaches 0.66, 0.9, 1.29, 1.95 and 1.50 Gy for "i" = 1, 2, 4, 12 and 24 hours. Dr is smaller for intestine; after abdominal irradiation with gamma rays, it reaches 1.99, 2.59, 2.74, 3.11, 3.34, 4.44 and 4.56 Gy for "i" = 1, 2, 3.5, 8, 12, 18 and 24 hours; after neutron irradiation, it reaches 0.13, 0.45, 0.42 and 1.33 Gy for "i" = 1.5, 3.5, 5.5 and 24 hours. After gamma irradiation, early repair is complete after 3.5 hours for intestine and needs 12 hours for lung.
通过对小鼠进行胸部照射后180天的半数致死剂量（LD50），评估其对d(50) + Be中子和60Coγ射线的肺耐受性。通过腹部照射后7天的LD50评估早期肠道耐受性。当单剂量Ds被分成两个相等的部分Di，且间隔不同时间间隔“i”时，确定达到LD50所需的额外剂量（Dr）（Dr = 2Di - Ds），对于肺和肠道，γ射线照射后的Dr大于中子照射后的Dr。胸部γ射线照射后，“i”分别为2、6、12和24小时时，Dr分别达到3.36、4.38、5.12和5.37 Gy；中子照射后，“i”分别为1、2、4、12和24小时时，Dr分别达到0.66、0.9、1.29、1.95和1.50 Gy。肠道的Dr较小；腹部γ射线照射后，“i”分别为1、2、3.5、8、12、18和24小时时，Dr分别达到1.99、2.59、2.74、3.11、3.34、4.44和4.56 Gy；中子照射后，“i”分别为1.5、3.5、5.5和24小时时，Dr分别达到0.13、0.45、0.42和1.33 Gy。γ射线照射后，肠道在3.5小时后早期修复完成，肺则需要12小时。
