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Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages.

作者信息

Yang Xianfa, Hu Boqiang, Hou Yu, Qiao Yunbo, Wang Ran, Chen Yingying, Qian Yun, Feng Su, Chen Jun, Liu Chang, Peng Guangdun, Tang Fuchou, Jing Naihe

机构信息

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

出版信息

Cell Res. 2018 May;28(5):593-596. doi: 10.1038/s41422-018-0010-1. Epub 2018 Feb 20.

DOI:10.1038/s41422-018-0010-1
PMID:29463899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5951795/
Abstract
摘要

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本文引用的文献

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Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer.胚外谱系的表观遗传限制反映了向癌症的体细胞转变。
Nature. 2017 Sep 28;549(7673):543-547. doi: 10.1038/nature23891. Epub 2017 Sep 20.
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Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos.在着床前胚胎中 H3K4me3 和 H3K27me3 染色质域的独特特征。
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Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo.空间转录组图谱揭示中囊胚期小鼠胚胎谱系命运和细胞身份的分子特征
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Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.染色质动力学以及G9a在小鼠早期发育过程中基因调控和增强子沉默中的作用。
Elife. 2015 Nov 9;4:e09571. doi: 10.7554/eLife.09571.
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Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing.单细胞重亚硫酸盐测序技术分析哺乳动物细胞的 DNA 甲基化组图谱。
Nat Protoc. 2015 May;10(5):645-59. doi: 10.1038/nprot.2015.039. Epub 2015 Apr 2.
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DNA methylation dynamics of the human preimplantation embryo.人类胚胎着床前的 DNA 甲基化动态。
Nature. 2014 Jul 31;511(7511):611-5. doi: 10.1038/nature13581. Epub 2014 Jul 23.
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.一种 EZH2 的选择性抑制剂可阻断 H3K27 甲基化并杀死突变淋巴瘤细胞。
Nat Chem Biol. 2012 Nov;8(11):890-6. doi: 10.1038/nchembio.1084. Epub 2012 Sep 30.
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells.二价染色质结构标记胚胎干细胞中的关键发育基因。
Cell. 2006 Apr 21;125(2):315-26. doi: 10.1016/j.cell.2006.02.041.
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A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters.对人类基因组中CpG二核苷酸的全基因组分析区分出两类不同的启动子。
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1412-7. doi: 10.1073/pnas.0510310103. Epub 2006 Jan 23.
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Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.通过解剖显微镜下的形态学标志对原肠胚形成期小鼠胚胎进行分期。
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