Alfimova Margarita V, Korovaitseva Galina I, Lezheiko Tatyana V, Golimbet Vera E
Mental Health Research Center, Kashirskoe Shosse 34, Moscow 115522, Russia.
Schizophr Res Treatment. 2017;2017:5763094. doi: 10.1155/2017/5763094. Epub 2017 Dec 31.
Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors. As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74). We searched for associations of rs16944, rs2243250, and VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals. A significant effect of the X SOB interaction was found, = 0.007 and = 0.028. We confirmed this effect using an extended sample of 373 individuals. Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, = 0.049. This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions. The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population. The T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.
文献表明，冬季出生对精神分裂症易感性的影响可能是由于产前感染导致促炎细胞因子表达增加，以及抗炎因子对其调节不足所致。由于免疫系统的反应取决于基因型，本研究评估了细胞因子基因与出生季节（SOB）对用分裂型人格问卷（SPQ - 74）测量的分裂型人格的交互作用。我们在278名健康个体的样本中搜索了rs16944、rs2243250和VNTR多态性、SOB及其与SPQ - 74总分的相互作用。发现X SOB相互作用有显著影响，= 0.007和= 0.028。我们使用373名个体的扩展样本证实了这一效应。冬季出生的纯合子CC显示出最高的SPQ总分，并且与冬季出生的T等位基因携带者有显著差异，= 0.049。这种差异在认知 - 感知和紊乱维度上得到了证实，但在人际维度上没有。这些发现与细胞因子基因与SOB相互作用可影响一般人群中分裂型人格特征变异性的假设一致。T等位基因似乎对冬季出生个体中阳性和紊乱型分裂型人格特征的发展具有保护作用。
