使用联芳基膦配体支持的Pd(i)二聚体预催化剂的布赫瓦尔德-哈特维希胺化反应。
Buchwald-Hartwig amination using Pd(i) dimer precatalysts supported by biaryl phosphine ligands.
作者信息
Kirlikovali Kent O, Cho Eunho, Downard Tyler J, Grigoryan Lilit, Han Zheng, Hong Sooji, Jung Dahee, Quintana Jason C, Reynoso Vanessa, Ro Sooihk, Shen Yi, Swartz Kevin, Ter Sahakyan Elizabeth, Wixtrom Alex I, Yoshida Brandon, Rheingold Arnold L, Spokoyny Alexander M
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA.
出版信息
Dalton Trans. 2018 Mar 12;47(11):3684-3688. doi: 10.1039/c8dt00119g.
We report the synthesis of air-stable Pd(i) dimer complexes featuring biaryl phosphine ligands. Catalytic experiments suggest that these complexes are competent precatalysts that can mediate cross-coupling amination reactions between aryl halides with both aliphatic and aromatic amine nucleophiles. This work represents an expansion of the air-stable precatalyst toolbox for Pd-catalyzed cross-coupling transformations.
我们报道了具有联芳基膦配体的空气稳定型钯（I）二聚体配合物的合成。催化实验表明，这些配合物是有效的预催化剂，可介导芳基卤化物与脂肪族和芳香族胺亲核试剂之间的交叉偶联胺化反应。这项工作代表了用于钯催化交叉偶联转化的空气稳定型预催化剂工具箱的扩展。
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