韩国抗中性粒细胞胞质抗体相关性血管炎患者的癌症发展：一项单中心研究。

Cancer development in Korean patients with ANCA-associated vasculitis: a single centre study.

机构信息

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul; and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.

出版信息

Clin Exp Rheumatol. 2018 Mar-Apr;36 Suppl 111(2):73-77. Epub 2018 Feb 14.

PMID:29465366

Abstract

OBJECTIVES

We investigated the incidence rate and type of cancer, and furthermore, estimated the standardised incidence ratios (SIRs) of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Korea.

METHODS

We retrospectively included 150 patients with AAV [81 patients with microscopic polyangiitis (MPA), 38 with granulomatosis with polyangiitis (GPA) and 31 patients with eosinophilic GPA (EGPA)], and reviewed their medical records. We collected demographic, clinical and laboratory data, and reviewed the use of glucocorticoid and immunosuppressive drugs administered until detection of cancer or last visit. We estimated the SIRs of cancer according to totality, gender, age, AAV variants and each type of cancer.

RESULTS

The mean age at diagnosis of AAV was 55.2 years and that at last visit was 59.5 years. The mean follow-up duration was 50.7 months. Four of 150 AAV patients had cancer (2.7%), and they got four different types of cancers including gastric cancer, lung cancer, prostate cancer and Non-Hodgkin lymphoma. Two patients exhibited gap-time from AAV to malignancy less than one year, and the rest of them exhibited gap-time of 8 and 6 years, respectively. The overall SIR of cancer in AAV patients was 1.43 (95% confidence interval 0.391, 3.671). The SIRs of cancer based on gender, and age at cancer or last visit, AAV variants and each type of cancer were not significant, either.

CONCLUSIONS

The risk of cancer is low in Korean patients with AAV.

摘要

目的

我们调查了癌症的发病率和类型，并进一步估算了韩国抗中性粒细胞胞质抗体（ANCA）相关性血管炎（AAV）患者的癌症标准化发病比（SIR）。

方法

我们回顾性纳入了 150 例 AAV 患者[81 例显微镜下多血管炎（MPA）、38 例肉芽肿性多血管炎（GPA）和 31 例嗜酸性粒细胞性 GPA（EGPA）]，并查阅了他们的病历。我们收集了人口统计学、临床和实验室数据，并查阅了癌症检出或末次就诊前糖皮质激素和免疫抑制剂的使用情况。我们根据总体情况、性别、年龄、AAV 变异型和每种癌症估算了癌症的 SIR。

结果

AAV 的诊断年龄和末次就诊年龄分别为 55.2 岁和 59.5 岁，平均随访时间为 50.7 个月。150 例 AAV 患者中有 4 例（2.7%）发生癌症，包括胃癌、肺癌、前列腺癌和非霍奇金淋巴瘤 4 种不同类型。2 例患者从 AAV 到恶性肿瘤的时间间隔小于 1 年，其余 2 例患者的时间间隔分别为 8 年和 6 年。AAV 患者的癌症总 SIR 为 1.43（95%置信区间 0.391，3.671）。基于性别、癌症或末次就诊时的年龄、AAV 变异型和每种癌症的 SIR 也无显著差异。