Zhao Chengtian, Wang Yuping
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Neuroreport. 2018 Apr 11;29(6):459-465. doi: 10.1097/WNR.0000000000000995.
Previous studies have reported that the insular cortex is involved in recognition memory, but it remains unclear which subarea of the insular cortex serves this function. To address this question, we examined 14 drug-resistant focal epilepsy patients implanted with stereotactic electrodes in the insular cortex. All participants performed a delayed match-to-sample task. Event-related potentials and spectrograms from each insular subarea were analyzed when the participants were exposed to identical (match condition) and different (mismatch condition) stimuli. Each of the insular subareas had a significantly different event-related potential within the investigated interval of recognition memory under both match and mismatch conditions. Moreover, we observed that most of contacts in the left anterior insula had a stronger high-gamma response under the mismatch condition than the match condition, whereas most of contacts in the right insula had a stronger high-gamma response under the match condition than the mismatch condition. Thus, distinct roles for each insular subarea in recognition memory were found in this study. The right insula appears to subserve recognition memory by focusing on processing identical information, whereas the left anterior insula seems to subserve conflict monitoring by focusing on processing different information.
先前的研究报告称，岛叶皮层参与识别记忆，但岛叶皮层的哪个亚区域发挥这一功能仍不清楚。为了解决这个问题，我们检查了14名在岛叶皮层植入立体定向电极的耐药性局灶性癫痫患者。所有参与者都执行了延迟匹配样本任务。当参与者暴露于相同（匹配条件）和不同（不匹配条件）刺激时，分析了每个岛叶亚区域的事件相关电位和频谱图。在匹配和不匹配条件下，每个岛叶亚区域在识别记忆的研究时间间隔内都有显著不同的事件相关电位。此外，我们观察到，在不匹配条件下，左前岛叶的大多数触点比匹配条件下有更强的高伽马反应，而右岛叶的大多数触点在匹配条件下比不匹配条件下有更强的高伽马反应。因此，本研究发现了每个岛叶亚区域在识别记忆中的不同作用。右岛叶似乎通过专注于处理相同信息来服务于识别记忆，而左前岛叶似乎通过专注于处理不同信息来服务于冲突监测。
