Belisle S, Love E J
Fertil Steril. 1986 Dec;46(6):1015-20.
We compared the efficacy and safety of cyproterone acetate (Shering AC, Berlin, FRG) at a low (Diane, 2 mg) or a high dose (Androcur, 100 mg) in the treatment of 158 patients with severe hirsutism. At baseline, no difference was observed in mean hirsutism total index (19.5 Diane versus 20.1 Androcur) or distribution (facial, bust, or abdomen). By the end of the study, patient loss in Diane and Androcur groups was 29.1% and 27.8%, respectively, and the mean percent difference in the scoring index was as follows: total, 24.6 Diane versus 30.8 Androcur, P less than 0.05; facial, 30.1 Diane versus 33.0 Androcur, P less than 0.10; bust, 12.1 Diane versus 31.2 Androcur, P less than 0.02; and abdomen, 20.1 Diane versus 31.2 Androcur, P less than 0.02. Except for breast tenderness (Diane greater than Androcur), amenorrhea, and weight gain, (Androcur greater than Diane), the incidence of side effects was comparable in both groups.
我们比较了低剂量（达英，2毫克）和高剂量（环丙孕酮，100毫克）醋酸环丙孕酮（德国柏林先灵公司生产）治疗158例重度多毛症患者的疗效和安全性。基线时，多毛症总指数平均值（达英为19.5，环丙孕酮为20.1）或分布（面部、胸部或腹部）无差异。研究结束时，达英组和环丙孕酮组的患者流失率分别为29.1%和27.8%，评分指数的平均百分比差异如下：总体，达英为24.6，环丙孕酮为30.8，P<0.05；面部，达英为30.1，环丙孕酮为33.0，P<0.10；胸部，达英为12.1，环丙孕酮为31.2，P<0.02；腹部，达英为20.1，环丙孕酮为31.2，P<0.02。除乳房压痛（达英组高于环丙孕酮组）、闭经和体重增加（环丙孕酮组高于达英组）外，两组副作用发生率相当。
