Spólnicka Magdalena, Pośpiech Ewelina, Adamczyk Jakub Grzegorz, Freire-Aradas Ana, Pepłońska Beata, Zbieć-Piekarska Renata, Makowska Żanetta, Pięta Anna, Lareu Maria Victoria, Phillips Christopher, Płoski Rafał, Żekanowski Cezary, Branicki Wojciech
Central Forensic Laboratory of the Police, Warsaw, Poland.
Malopolska Centre of Biotechnology of the Jagiellonian University, Krakow, Poland.
Aging (Albany NY). 2018 Feb 15;10(2):241-252. doi: 10.18632/aging.101385.
Recent progress in epigenomics has led to the development of prediction systems that enable accurate age estimation from DNA methylation data. Our objective was to track responses to intense physical exercise of individual age-correlated DNA methylation markers and to infer their potential impact on the aging processes. The study showed accelerated DNA hypermethylation for two CpG sites in and . Both markers predicted the investigated elite athletes to be several years older than controls and this effect was more substantial in subjects involved in power sports. Accordingly, the complete 5-CpG model revealed age acceleration of elite athletes (=1.503x10) and the result was more significant amongst power athletes (P=1.051x10). The modified methylation of and in top athletes may be accounted for by the biological roles played by these genes. Their known anti-tumour and anti-inflammatory activities suggests that intense physical training has a complex influence on aging and potentially launches signalling networks that contribute to the observed lower risk of elite athletes to develop cardiovascular disease and cancer.
表观基因组学的最新进展促使了预测系统的发展，该系统能够根据DNA甲基化数据准确估计年龄。我们的目标是追踪个体年龄相关DNA甲基化标记对高强度体育锻炼的反应，并推断它们对衰老过程的潜在影响。研究表明，[具体位置1]和[具体位置2]的两个CpG位点的DNA超甲基化加速。这两个标记都预测被研究的精英运动员比对照组年龄大几岁，并且这种效应在从事力量运动的受试者中更为显著。因此，完整的5-CpG模型显示精英运动员的年龄加速（=1.503x10），在力量运动员中结果更显著（P=1.051x10）。顶级运动员中[具体基因1]和[具体基因2]的甲基化修饰可能是由这些基因所起的生物学作用导致的。它们已知的抗肿瘤和抗炎活性表明，高强度体育训练对衰老有复杂的影响，并可能启动信号网络，这有助于解释观察到的精英运动员患心血管疾病和癌症风险较低的现象。
