BRIP1基因的四种常见多态性（rs2048718、rs4988344、rs4986764和rs6504074）与癌症风险：来自13716例癌症患者和15590例无癌对照的证据。
Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls.
作者信息
Liu Di, Zheng Yi, Wang Meng, Deng Yujiao, Lin Shuai, Zhou Linghui, Yang Pengtao, Dai Cong, Xu Peng, Hao Qian, Song Dingli, Kang Huafeng, Dai Zhijun
机构信息
Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
出版信息
Aging (Albany NY). 2018 Feb 16;10(2):266-277. doi: 10.18632/aging.101388.
Previous studies have showed the associations between various BRCA1-interacting protein 1 () polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population ( < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population ( < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people ( < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.
以往研究显示了各种乳腺癌1号基因相互作用蛋白1（）多态性与癌症风险之间的关联。但是，这些结果并不一致。这项基于18项研究的荟萃分析涉及13716例癌症患者和15590例无癌对照，旨在评估乳腺癌1号基因相互作用蛋白1的4个常见单核苷酸多态性（rs2048718、rs4988344、rs4986764和rs6504074）与癌症风险之间的关系。结果显示，在总体人群中，rs2048718或rs4986764与宫颈癌风险降低相关，而非乳腺癌（<0.05）。然而，rs6504074与总体人群中的妇科癌症风险相关（<0.05）。按种族进行的进一步分层分析表明，所有4种多态性（rs2048718、rs4988344、rs4986764和rs6504074）在中国人群中均与癌症易感性密切相关（<0.05）。这项荟萃分析表明，rs6504074可能在总体人群中降低妇科癌症风险。Rs4988344、rs4986764和rs6504074与中国人群中降低癌症风险显著相关。
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