Int J Gynecol Cancer. 2018 Mar;28(3):493-499. doi: 10.1097/IGC.0000000000001202.
The present study retrospectively determined the outcomes and prognoses in stage I mucinous ovarian carcinoma according to histological type (ie, expansile or infiltrative).
A centralized pathologic review of tumors in patients treated from 1976 to 2016 for ovarian mucinous carcinoma was performed by 2 expert pathologists according to the 2014 World Health Organization classification. Only patients with stage I disease were analyzed. Tumors were typed as expansile or infiltrative and oncological issues analyzed.
A total of 114 cases were reviewed. Fifty were excluded (stage > I in 30 cases and no accessibility to a pathological review for 20 cases). Thus, 64 patients fulfilled the inclusion criteria: 29 had expansile-type and 35 infiltrative-type disease. The characteristics of both groups of patients were comparable, except the use of nodal staging surgery, which was more frequent in patients with infiltrative type. The International Federation of Gynecology and Obstetrics stages in expansile and infiltrative types were as follows: IA in 13 (45%) and 20 (57%), and IC in 16 (55%) and 15 (43%), respectively. Recurrence occurred in 3 patients with expansile type and 6 patients with infiltrative type. Two cases of expansile recurrence had pelvic recurrence and were salvaged after secondary surgery and chemotherapy, whereas 5 cases of infiltrative recurrence had extrapelvic spread and died from disease or were alive with progressive disease.
Recurrence occurred in both types of stage I mucinous ovarian cancer. However, lethal recurrences were observed mainly in infiltrative type.
本研究回顾性地根据组织学类型（即扩张型或浸润型）确定了 I 期黏液性卵巢癌的结局和预后。
通过 2 名专家病理学家根据 2014 年世界卫生组织分类，对 1976 年至 2016 年期间接受卵巢黏液性癌治疗的患者的肿瘤进行集中病理复查。仅分析 I 期疾病患者。将肿瘤分为扩张型或浸润型，并分析肿瘤学问题。
共复查了 114 例。排除了 50 例（30 例分期>I 期，20 例无法进行病理复查）。因此，符合纳入标准的患者共有 64 例：29 例为扩张型，35 例为浸润型。两组患者的特征相似，除浸润型患者更常进行淋巴结分期手术外。扩张型和浸润型国际妇产科联合会分期分别为 IA 期 13 例（45%）和 20 例（57%），IC 期 16 例（55%）和 15 例（43%）。扩张型中有 3 例复发，浸润型中有 6 例复发。2 例扩张型复发患者出现盆腔复发，经二次手术和化疗后得以挽救，而 5 例浸润型复发患者出现盆腔外播散，死于疾病或仍有疾病进展。
两种类型的 I 期黏液性卵巢癌均有复发。然而，浸润型主要观察到致命性复发。
