Tsuchimoto S
Hokkaido Igaku Zasshi. 1986 Sep;61(5):776-99.
In the present study, rat orthotopic liver grafting was performed in order to investigate genetical, immunological and pathological aspects of liver transplantation. In the rat, MHC (RT1) incompatible liver grafts are mostly rejected in an acute fashion like other organs, and Class II antigen-barrier had a stronger effects on the survival of liver grafts than that of class I antigens. But in Some combinations, full RT1 incompatible grafts can survive indefinitely. The mechanisms of long survival of liver grafts are complicated dynamically but regulated systematically. While the hepatocytes are regenerating from the damage by the attack of the host immune reactions, the condition of host immune response is gradually changed from positive to negative. Immunosuppressive humoral factors (anti-Ia antibodies, anti-idiotypic antibodies, class I-like antigens secreted from hepatocytes, etc.) are produced and later suppressor cells are induced. Both of them can suppress the immune reactions (MLR, CTL induction etc.) successfully. These results indicate that liver grafts stand strong having potential regenerating activity and changing the host anti-graft immunity to immunologically unresponsive state.
在本研究中，进行大鼠原位肝移植以研究肝移植的遗传学、免疫学和病理学方面。在大鼠中，MHC（RT1）不相容的肝移植大多像其他器官一样以急性方式被排斥，并且II类抗原屏障对肝移植存活的影响比I类抗原更强。但在某些组合中，完全RT1不相容的移植物可以无限期存活。肝移植长期存活的机制动态复杂但系统调节。当肝细胞从宿主免疫反应攻击造成的损伤中再生时，宿主免疫反应的状态逐渐从阳性变为阴性。产生免疫抑制体液因子（抗Ia抗体、抗独特型抗体、肝细胞分泌的I类样抗原等），随后诱导抑制细胞。它们都能成功抑制免疫反应（混合淋巴细胞反应、细胞毒性T淋巴细胞诱导等）。这些结果表明，肝移植具有强大的潜在再生活性，并能将宿主抗移植物免疫改变为免疫无反应状态。
