在热中性环境下棕色脂肪组织密度和脉搏率变异性的季节性差异。
Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment.
作者信息
Nirengi Shinsuke, Sakane Naoki, Amagasa Shiho, Wakui Sawako, Homma Toshiyuki, Kurosawa Yuko, Hamaoka Takafumi
机构信息
Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Kyoto, 612-8555, Japan.
Department of Preventive Medicine and Public Health, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan.
出版信息
J Physiol Anthropol. 2018 Feb 21;37(1):6. doi: 10.1186/s40101-018-0166-x.
BACKGROUND
Brown adipose tissue (BAT) is sympathetically activated and induces thermogenesis during cold exposure, thereby influencing energy expenditure and body fat levels. The very low frequency (VLF) components of pulse rate variability could be a form of thermogenic sympathetic nervous activity, but no clear relationship has yet been reported between VLF activity and BAT density. We therefore aimed to evaluate the association between them.
METHODS
We enrolled 20 adults in winter and 20 matched adults in summer. We assessed BAT densities based on total hemoglobin concentrations ([total-Hb]) measured with near-infrared time-resolved spectroscopy. We calculated VLF activity from pulse rate variability measurements.
RESULTS
BAT density ([total-Hb]; winter 70.5 ± 17.0 μM, summer 57.8 ± 18.3 μM) and VLF activity (winter 6.7 ± 0.8, summer 6.1 ± 0.9) were significantly higher in winter than in summer (P < 0.05). However, there was no significant correlation between VLF activity and BAT density in either season.
CONCLUSION
Each parameter exhibited seasonal variation, but we failed to observe any significant correlations.
背景
棕色脂肪组织（BAT）在寒冷暴露期间会被交感神经激活并诱导产热，从而影响能量消耗和体脂水平。脉搏率变异性的极低频（VLF）成分可能是产热交感神经活动的一种形式，但VLF活动与BAT密度之间尚未有明确的关系报道。因此，我们旨在评估它们之间的关联。
方法
我们招募了20名冬季成年人和20名匹配的夏季成年人。我们基于用近红外时间分辨光谱法测量的总血红蛋白浓度（[总-Hb]）评估BAT密度。我们从脉搏率变异性测量中计算VLF活动。
结果
BAT密度（[总-Hb]；冬季70.5±17.0μM，夏季57.8±18.3μM）和VLF活动（冬季6.7±0.8，夏季6.1±0.9）在冬季显著高于夏季（P<0.05）。然而，在两个季节中，VLF活动与BAT密度之间均无显著相关性。
结论
每个参数均表现出季节性变化，但我们未观察到任何显著相关性。
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