Kohzuki M, Abe K, Yasujima M, Tanno M, Kasai Y, Sato M, Omata K, Kudo K, Takeuchi K, Yoshinaga K
J Hypertens Suppl. 1986 Oct;4(3):S487-9.
The chronic effect of a synthetic atrial natriuretic factor (ANF) of 25 amino acid residues on the development of hypertension in the 6-week-old spontaneously hypertensive rat (SHR) was assessed. The SHR, on regular diets or given 1% NaCl solution for drinking, were continuously infused with ANF (150 micrograms/kg per day) or vehicle (physiological saline) as controls for up to 14 days. The ANF attenuated transiently the development of hypertension in the sodium-loaded SHR, but the blood pressure returned to control levels by day 5. In SHR on regular diets ANF did not affect the development of hypertension. In addition, ANF did not induce any significant changes in urine volume, fluid intake, urinary sodium and potassium excretion, heart rate, heart weight or haematocrit in young SHR on either normal or increased sodium intake when compared with those in vehicle-infused SHR. These results suggest that ANF may exert some role via a vascular effect at the early stage of development of hypertension in young sodium-loaded SHR.
评估了一种由25个氨基酸残基组成的合成心房利钠因子（ANF）对6周龄自发性高血压大鼠（SHR）高血压发展的慢性影响。将正常饮食或饮用1%氯化钠溶液的SHR连续输注ANF（每天150微克/千克）或作为对照的赋形剂（生理盐水），持续14天。ANF可短暂减轻钠负荷SHR的高血压发展，但到第5天时血压恢复到对照水平。在正常饮食的SHR中，ANF不影响高血压的发展。此外，与输注赋形剂的SHR相比，在正常或增加钠摄入的年轻SHR中，ANF对尿量、液体摄入量、尿钠和钾排泄、心率、心脏重量或血细胞比容均未引起任何显著变化。这些结果表明，ANF可能在年轻钠负荷SHR高血压发展的早期阶段通过血管效应发挥某种作用。
