Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Chem Soc Rev. 2018 Mar 5;47(5):1783-1810. doi: 10.1039/c7cs00615b.
Oxazoline-containing ligands have been widely employed in numerous asymmetric catalytic reactions. Pyridine-oxazoline-type ligands, a class of hybrid ligands, were designed earlier than bisoxazoline and phosphine-oxazoline ligands; however, their unique properties have only been discovered recently. Pyridine-oxazoline-type chiral ligands are rapidly becoming popular for use in asymmetric catalysis, especially for several new and efficient asymmetric methodologies. Several types of challenging asymmetric reactions have been discovered recently using pyridine-oxazoline-type ligands showing their special properties and potential for future application in a wide range of new catalytic methodologies. This review provides an overview of this field, with the aim of highlighting both ligand design and synthetic methodology development.
含恶唑啉配体在众多不对称催化反应中得到了广泛应用。吡啶恶唑啉型配体是一类杂化配体，其设计时间早于双恶唑啉和膦恶唑啉配体，但它们的独特性质直到最近才被发现。吡啶恶唑啉型手性配体在不对称催化中迅速流行起来，特别是在几种新的、高效的不对称方法中。最近使用吡啶恶唑啉型配体发现了几种具有挑战性的不对称反应，这表明它们具有特殊的性质和在广泛的新型催化方法中的潜在应用。本文综述了这一领域，旨在强调配体设计和合成方法的发展。
