[Correlation between HLA-DB1 genes and susceptibility to echinococcosis in Tibetan population in Tibetan Plateau].
作者信息
Shu-Feng Gao, Xiu-Min Han, Xue-Fei Zhang, Yong-Shun Wang, Wei Wang, Ya-Min Guo, Yong-Shou Li
机构信息
Qinghai People's Hospital, Xining 810000, China.
Qinghai Provincial Institute of Endemic Disease Prevention and Control, China.
出版信息
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017 Oct 23;29(5):602-606. doi: 10.16250/j.32.1374.2017075.
OBJECTIVE
To determine the susceptibility genes and resistance genes in HLA-DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases, so as to provide the references for the research of the genetic characteristics and infection mechanism of Tibetan hydatid diseases.
METHODS
The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases (63 and 73 cases respectively) in Yushu and Guoluo Tibetan Autonomous Prefecture, and unrelated healthy people (60 cases) in this area were selected as the study subjects. The polymerase chain reaction-sequence based typing (PCR-SBT) technique was applied for genotyping of HLA-DRB1, and the comparison of the gene frequency.
RESULTS
The frequency of HLA-DRB1*04 in the alveolar/cystic echinococcosis group was lower than that in the control group ( = 4.71, 4.31, both < 0.05).
CONCLUSIONS
HLA-DRB1*04 genotypes may be associated with the resistance of cystic and alveolar echinococcosis and its resistance genes.
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