Henry J M, Filburn C R, Joseph J A, Roth G S
Neurobiol Aging. 1986 Sep-Oct;7(5):357-61. doi: 10.1016/0197-4580(86)90162-4.
Both D1 and D2 dopamine receptor subtypes are lost from striata as Wistar rats age. The magnitude of loss differs slightly for the two subtypes (approximately 30% for D1, approximately 40% for D2) as does the temporal pattern (progressive loss from 3 to 24 months for D2, no decrease in D1 after 12 months) although most D2 loss also occurs in the first half of the lifespan. Dopamine stimulated adenylate cyclase activity also declines during striatal aging in a manner roughly proportioned to D1 receptor loss.
随着Wistar大鼠年龄增长，纹状体中的D1和D2多巴胺受体亚型均会丧失。两种亚型的丧失程度略有不同（D1约为30%，D2约为40%），时间模式也不同（D2从3个月到24个月逐渐丧失，D1在12个月后无下降），尽管大多数D2的丧失也发生在寿命的前半段。在纹状体衰老过程中，多巴胺刺激的腺苷酸环化酶活性也会下降，其下降方式与D1受体丧失大致成比例。
