Notaro Eliza, Fett Nicole, Shinohara Michi M
Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
Dermatol Online J. 2017 Sep 15;23(9):13030/qt7p5986sm.
Exposure to even physiologic doses of glucocorticoids can reduce one's bone mass and increase risk for osteoporotic fracture. There currently exists a wide variation in clinician approach to the assessment and management of glucocorticoid-induced osteoporosis (GIO). Our objectives were to characterize Pacific Northwest dermatology providers' general practices, assessment of risk for GIO, and preferred GIO prophylaxis measures by way of survey. To identify whether knowledge deficits exist with respect to preventing and managing GIO in dermatology patients.
A self-administered, 22-question survey was sent electronically to respondent population. Surveyed population composed of 392 dermatology providers of the Washington State Dermatology Association and Oregon Dermatology Society registries. Survey responses were collected anonymously via Catalyst WebQ.
Respondents over-estimated fracture risk and reported they would prescribe antiresorptive medications at a less-than-adequate rate. When given clinical scenarios and asked to assess risk of major osteoporotic fracture, respondents frequently overestimated risk compared to that estimated by the FRAX tool (67%-71%). When asked directly if one would prescribe bisphosphonates as GIO prophylaxis for a high-risk patient, only 49% responded always/almost always.
This study suggests that a knowledge deficit exists within dermatology with respect to prevention and screening of GIO. The resultant practice gap is likely contributing to morbidity and mortality for dermatology patients requiring chronic glucocorticoid use for dermatologic disorders. Provider variability in practices suggests that dermatology could benefit from additional education in assessment and treatment of GIO, as well as a clear set of guidelines for GIO management.
即使接触生理剂量的糖皮质激素也会降低骨量并增加骨质疏松性骨折的风险。目前临床医生对糖皮质激素性骨质疏松症(GIO)的评估和管理方法存在很大差异。我们的目标是通过调查来描述太平洋西北地区皮肤科医生的一般做法、对GIO风险的评估以及首选的GIO预防措施。以确定在皮肤科患者中预防和管理GIO方面是否存在知识缺陷。
通过电子方式向应答人群发送一份包含22个问题的自填式调查问卷。被调查人群包括华盛顿州皮肤科协会和俄勒冈州皮肤科协会登记处的392名皮肤科医生。通过Catalyst WebQ匿名收集调查问卷的回复。
受访者高估了骨折风险,并报告他们开具抗吸收药物的比例不足。当给出临床病例并要求评估主要骨质疏松性骨折的风险时,与FRAX工具估计的风险相比,受访者经常高估风险(67%-71%)。当直接询问是否会为高危患者开具双膦酸盐作为GIO预防药物时,只有49%的人回答总是/几乎总是会开具。
这项研究表明,皮肤科在GIO的预防和筛查方面存在知识缺陷。由此产生的实践差距可能导致需要长期使用糖皮质激素治疗皮肤病的患者出现发病和死亡情况。医生做法的差异表明,皮肤科可能会从GIO评估和治疗方面的额外教育以及一套明确的GIO管理指南中受益。