ten Haaf J A, van Wimersma Greidanus T B, Maigret C, De Wied D
Neuroendocrinology. 1986;44(1):102-7. doi: 10.1159/000124629.
beta-Endorphin (beta E) exerts a strong inhibitory action on plasma vasopressin (VP) of rats, after intracerebroventricular, but not after subcutaneous injection of the drug. This effect is time- and dose-dependent. Also in the water-deprived rat, this treatment leads to a strong decrease of plasma VP levels. When rats treated with histamine (HIS) intracerebroventricularly to stimulate VP levels are injected with beta E to HIS treatment, beta E partially prevents the increase of plasma VP levels. Naloxone subcutaneously administered, antagonizes the effect of beta E in all the situations we investigated. Opioid receptors, located in the brain as well as in the pituitary, are possibly involved in these processes.
β-内啡肽（βE）经脑室注射而非皮下注射后，对大鼠血浆血管加压素（VP）具有强烈的抑制作用。这种作用具有时间和剂量依赖性。在缺水的大鼠中，这种处理也会导致血浆VP水平大幅下降。当给经脑室注射组胺（HIS）以刺激VP水平的大鼠注射βE时，βE可部分阻止血浆VP水平的升高。皮下注射纳洛酮可在我们研究的所有情况下拮抗βE的作用。位于脑和垂体中的阿片受体可能参与了这些过程。
